Nodal T-cell lymphoma with eosinophilic infiltration and sclerosing fibroplasia in a cat with eosinophilia.

An 8-year-old castrated male mixed-breed cat presented with an abdominal mass of unknown origin, accompanied by eosinophilia. Autopsy revealed mild-to-severe enlargement of lymph nodes throughout the body and multiple nodules in the lungs. Histopathologically, the lymph nodes showed severe fibroplasia and infiltration by a large number of eosinophils and fewer tumor cells, exhibiting large-sized lymphoid cell morphology.

Prevalence and Factors Related to High Risk of Multiple Chemical Sensitivity among Japanese High School Students.

Multiple chemical sensitivity (MCS) onset in minors can greatly impact learning and future employment. This study investigated the prevalence of MCS and related factors in high school students to determine whether it was the same as in adults. A comprehensive survey was conducted on 80 high schools in Gunma Prefecture, Japan.

Current understanding of comparative pathology and prospective research approaches for canine hemangiosarcoma.

Hemangiosarcoma (HSA) is a malignant tumor originating from endothelial cells. HSA typically develops in dogs, but is rare in other animals, including humans. Although surgery and chemotherapy are conventional treatments for HSA, neither treatment can significantly improve patient prognosis.

Virological, pathological, and glycovirological investigations of an Ezo red fox and a tanuki naturally infected with H5N1 high pathogenicity avian influenza viruses in Hokkaido, Japan.

In winter/spring 2021-2022, high pathogenicity avian influenza viruses (HPAIVs) that are genetically closely related to each other were detected worldwide. In a public garden in Sapporo, Hokkaido, Japan, a crow die-off by HPAIV infection occurred from March 29 to May 18, 2022. During the event, H5N1 HPAIVs were isolated from an Ezo red fox (Vulpes vulpes schrencki) and a tanuki (Nyctereutes procyonoides albus) found in the same garden.

Retrospective evaluation of clinical signs, clinical course, and prognosis between dogs with left atrial rupture secondary to myxomatous mitral valve disease and those with neoplastic cardiac tamponade (2015-2019): 70 cases.

Objective: To describe the clinical signs, clinical course, and prognosis of suspected left atrial rupture (LAR) secondary to myxomatous mitral valve disease (MMVD) in dogs and to compare them with dogs with suspected neoplastic cardiac tamponade (NCT).

Design: Retrospective study from November 2015 to October 2019 SETTING: An out-of-hours Emergency Animal Hospital.

Animals: Twenty-three dogs with LAR secondary to MMVD (LAR group) and 47 dogs with NCT (NCT group).

Manipulating histone acetylation leads to antitumor effects in hemangiosarcoma cells.

Canine hemangiosarcoma (HSA) is a malignant tumour derived from endothelial cells. No effective treatment has yet been developed because of the lack of understanding of its pathogenesis. Histone acetylation, an epigenetic modification, is highly associated with cancer pathogenesis.

Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages.

Hemangiosarcoma (HSA) is a malignant tumor derived from endothelial cells. Tumor-associated macrophages are one of the major components of tumor microenvironment and crucial for cancer development. The presence and function of macrophages in HSA have not been studied because there is no syngeneic model for HSA.

Selenoneine, a novel selenium-containing compound, mediates detoxification mechanisms against methylmercury accumulation and toxicity in zebrafish embryo.

The selenium (Se)-containing antioxidant selenoneine (2-selenyl-N α,N α,N α-trimethyl-L-histidine) has recently been discovered to be the predominant form of organic Se in tuna blood. Although dietary intake of fish Se has been suggested to reduce methylmercury (MeHg) toxicity, the molecular mechanism of MeHg detoxification by Se has not yet been determined. Here, we report evidence that selenoneine accelerates the excretion and demethylation of MeHg, mediated by a selenoneine-specific transporter, organic cations/carnitine transporter-1 (OCTN1).

Stress coping ability in nursing students: studies on the influence factor of Sense of Coherence (SOC).

The researchers conducted an investigation on factors influencing stress coping ability, referred to as a Sense of Coherence (SOC). 278 students in the 2nd to 4th year of "A" University nursing program were subjected to this survey, and the response rate was 75.5%.

Consideration of grand design for the care environment in hospitals--smell, lighting and sound.

We investigated grand designs for the care environment in hospitals, focusing on smell, lighting and sound, based on a database of observed domestic general hospitals (12 institutions), consisting of 1235 photographs and descriptive data. As a result, we identified four areas that should be incorporated into grand designs for this type of care environment: [1] The smell environment with (1) the exclusion of "odors", and (2) regulation of "fragrances"; [2] the lighting environment with lighting that successfully incorporates nature; [3] the sound environment that incorporates (1) pleasant sounds, and (2) the exclusion of excess noise; and [4] a natural environment and a healing space where individuals can feel at ease. The most important challenges in reform of the care environment are an emphasis on an approach that employs the senses, and the necessity of raising the awareness of healthcare providers in relation to this type of environment.