11-Azaartemisinin derivatives bearing halogenated aromatic moieties: Potent anticancer agents with high tumor selectivity.

While artemisinin and its derivatives, including 11-azaartemisinin-based compounds, have shown promising anticancer activity, the integration of halogens into aromatic structures can amplify drug potency, metabolic stability, and selectivity. Herein, we present the synthesis of new novel 11-azaartemisinin derivatives bearing halogenated aromatic moieties connected via 1,2,3-triazole bridges and evaluate their anticancer activities against three human tumor cell lines: epidermoid carcinoma (KB), hepatocellular carcinoma (HepG2), and human lung adenocarcinoma (A549). Among the synthesized compounds, six of them (8c-h) displayed good to excellent antiproliferative activity in the low micromolar range across all three human cancer cell lines.

Competing social identities and intergroup discrimination: Evidence from a framed field experiment with high school students in Vietnam.

We conducted a framed field experiment to explore a situation where individuals have potentially competing social identities to understand how group identification and socialisation affect in-group favouritism and out-group discrimination. The Dictator Game and the Trust Game were conducted in Vietnam's Ho Chi Minh City on two groups of high school students with different backgrounds, i.e.

Are California's Local Flavored Tobacco Sales Restrictions Effective in Reducing the Retail Availability of Flavored Tobacco Products? A Multicomponent Evaluation.

Introduction: Flavored tobacco appeals to new users. This paper describes evaluation results of California's early ordinances restricting flavored tobacco sales.

Methods: A multicomponent evaluation of proximal policy outcomes involved the following: (a) tracking the reach of local ordinances; (b) a retail observation survey; and (c) a statewide opinion poll of tobacco retailers.

Vaping identity in adolescent e-cigarette users: A comparison of norms, attitudes, and behaviors.

Introduction: Using the tenets underlying social identity theory and the theory of planned behavior, the current study compared the perceptions, attitudes, and behaviors of e-cigarette users that reported vaping as self-defining ("vapers") compared to users that denied vaping was central to their identity ("non-vapers").

Method: Secondary analyses of data from the 2017-2018 California Student Tobacco Survey were utilized. A weighted, multivariable regression model (N = 82,217) compared the demographic characteristics, beliefs, and behaviors of vapers and non-vapers.

Assessment of Underage Sales Violations in Tobacco Stores and Vape Shops.

This study assesses whether the US Food and Drug Administration regulation to limit the sale of flavored tobacco products to age-restricted locations is adequate based on a 1-year review of violations rates in age-restricted shops.

Evaluation of California's 'Tobacco 21' law.

Introduction: California's law raising the minimum tobacco sales age to 21 went into effect on 9 June 2016. This law, known as 'Tobacco 21' or 'T21', also expanded the definition of tobacco to include electronic smoking devices. This paper describes the T21 evaluation plan and initial evaluation results.

Retrotransposons Are the Major Contributors to the Expansion of the Muller F Element.

The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (∼5.2 Mb) is the smallest chromosome in , but it is substantially larger (>18.

Absenteeism due to Functional Limitations Caused by Seven Common Chronic Diseases in US Workers.

Objective: The study examined the relationship between functional limitation due to chronic diseases and absenteeism among full-time workers. The studied chronic diseases include arthritis/rheumatism, cancer, diabetes, heart disease, hypertension, lung disease, and stroke.

Methods: We analyzed data from the 2011 to 2013 National Health Interview Survey.

Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D.

Development and validation of the medication-based disease burden index.

Background: Medication lists offer an alternative source of data on comorbidities and disease burden.

Objective: To develop and validate the Medication-Based Disease Burden Index (MDBI).

Methods: A list of medications corresponding to the leading causes of global death was pilot tested and finalized by an expert panel.