Short-acting beta agonist, antibiotics, oral corticosteroid and association with mortality and cardiopulmonary events in patients with COPD: a retrospective cohort study in Alberta, Canada.

Objective: The purpose of the study was to examine the association between short-acting beta agonist (SABA), antibiotic and oral corticosteroid (OCS) use and mortality and cardiopulmonary outcomes in chronic obstructive pulmonary disease (COPD).

Design: Retrospective cohort study using administrative health data from 1 April 2011 to 31 March 2020.

Setting: Alberta, Canada.

Interference of potassium chloride and diammonium hydrogen phosphate on volumetric, viscometric and spectroscopic properties of aqueous nicotinamide.

Understanding how vitamins and fertilizers interact in aquatic environments is crucial for managing water quality, protecting aquatic life, and promoting sustainable agricultural practices. The molecular interactions between nicotinamide (NA) and two fertilizers, potassium chloride (KCl) and diammonium hydrogen phosphate (DAP), were examined by density () and viscosity () measurements in order to investigate and analyze the solvation behavior that occurs in the ternary solutions (NA + KCl/DAP + water). All of these investigations were conducted at temperatures ranging from 293.

Early Postoperative Outcome Following Laparoscopic Surgeries in Rectal Malignancies.

Rectal malignancies that require abdominoperineal resection (APR) and Anterior resection (AR) is very common. Laparoscopic APR or AR can be a better option. This study observed the feasibility of this newer technique for alternative to conventional open method.

Light microscopic morphology of blood cells of non-descript indigenous Zoar chicken of Mizoram, India.

Identifying and analysing distinct blood cells is crucial for the diagnosis and treatment of diseases in the field of biomedicine. The present study was undertaken to study the cytomorphological and cytochemical characteristics of the blood cells of Zoar, a non-descript indigenous breed of chicken extensively reared under backyard poultry farming in Mizoram, India. For this study, 2 mL of blood samples were aseptically collected from the wings veins of 12 chickens and were processed for light microscopic study under standard protocols.

Red blood cell indices in different hemoglobinopathies: A cross-sectional study in Eastern India.

Introduction: Beta thalassemia and hemoglobin (HbE)-related hemoglobinopathies are common public health problems in developing countries. High-performance liquid chromatography (HPLC) is currently the diagnostic test of choice for carrier detection, but it is costly. Hence, some initial screening and complementary tests are required, which can be affordable.

Techno-economic analysis of underground hydrogen storage in Europe.

Hydrogen storage is crucial to developing secure renewable energy systems to meet the European Union's 2050 carbon neutrality objectives. However, a knowledge gap exists concerning the site-specific performance and economic viability of utilizing underground gas storage (UGS) sites for hydrogen storage in Europe. We compile information on European UGS sites to assess potential hydrogen storage capacity and evaluate the associated current and future costs.

Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia.

Alzheimer's disease (AD) is an age-associated neurodegenerative disorder characterized by progressive neuronal loss and pathological accumulation of the misfolded proteins amyloid-β and tau. Neuroinflammation mediated by microglia and brain-resident macrophages plays a crucial role in AD pathogenesis, though the mechanisms by which age, genes, and other risk factors interact remain largely unknown. Somatic mutations accumulate with age and lead to clonal expansion of many cell types, contributing to cancer and many non-cancer diseases.

Heightened long-term cardiovascular risks after exacerbation of chronic obstructive pulmonary disease.

Objective: To examine the risk of adverse cardiovascular (CV) events following an exacerbation of chronic obstructive pulmonary disease (COPD).

Methods: This retrospective cohort study identified patients with COPD using administrative data from Alberta, Canada from 2014 to 2019. Exposure periods were 12 months following moderate or severe exacerbations; the reference period was time preceding a first exacerbation.

Asthma-related emergency admissions and associated healthcare resource use in Alberta, Canada.

Background: There is a lack of real-world research assessing asthma management following asthma-related emergency department (ED) discharges. The objective of this study was to characterise follow-up care, healthcare resource use (HCRU) and medical costs following ED admissions in Alberta, Canada.

Methods: A retrospective cohort study was conducted on adults with asthma using longitudinal population-based administrative data from Alberta Health Services.

Glial dysregulation in the human brain in fragile X-associated tremor/ataxia syndrome.

Short trinucleotide expansions at the FMR1 locus are associated with the late-onset condition fragile X-associated tremor/ataxia syndrome (FXTAS), which shows very different clinical and pathological features from fragile X syndrome (associated with longer expansions), with no clear molecular explanation for these marked differences. One prevailing theory posits that the shorter, premutation expansion uniquely causes extreme neurotoxic increases in FMR1 mRNA (i.e.

Embryonic and Larval Development of Stinging Catfish, , in Relation to Climatic and Water Quality Parameters.

In terms of hatchery-based seed production, one of the most important aquaculture species in Bangladesh is the stinging catfish (). Scientific and evidence-based embryonic and larval development research on this fish species in the context of climate change is limited. This experimental study was conducted via induced breeding of stinging catfish using a conventional hatchery system, rearing the larvae in hapas placed in ponds.

Utility of Scrape Cytology in Management of Ovarian Neoplasms: a Cross-sectional Study in a Tertiary Care Hospital of Eastern India.

Ovarian tumors are one of the most common gynecological neoplasms worldwide affecting women of all ages. As preoperative diagnosis is often inaccurate, intraoperative diagnostic modalities play indispensable role in management of ovarian tumors to avoid unnecessary extensive surgery. Although reliable, frozen section is highly expensive for resource-poor developing countries.

TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.

Sonic hedgehog signaling regulates processes of embryonic development across multiple tissues, yet factors regulating context-specific Shh signaling remain poorly understood. Exome sequencing of families with polymicrogyria (disordered cortical folding) revealed multiple individuals with biallelic deleterious variants in , which encodes a multi-pass transmembrane protein of unknown function. null mice demonstrated holoprosencephaly, craniofacial midline defects, eye defects, and spinal cord patterning changes consistent with impaired Shh signaling, but were without limb defects, suggesting a CNS-specific role of Tmem161b.

Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.

Kinesins are canonical molecular motors but can also function as modulators of intracellular signaling. KIF26A, an unconventional kinesin that lacks motor activity, inhibits growth-factor-receptor-bound protein 2 (GRB2)- and focal adhesion kinase (FAK)-dependent signal transduction, but its functions in the brain have not been characterized. We report a patient cohort with biallelic loss-of-function variants in KIF26A, exhibiting a spectrum of congenital brain malformations.

SABA use as an indicator for asthma exacerbation risk: an observational cohort study (SABINA Canada).

Background: Patients with asthma use short-acting β-agonists (SABA) to relieve symptoms but SABA alone does not treat underlying inflammation. Thus, over-reliance on SABA may result in poor asthma control and negative health outcomes.

Objective: To describe use of SABA and characterise the relationship with severe exacerbations in the Canadian provinces of Nova Scotia (NS) and Alberta (AB).

Synbiotic Effects of Fermented Rice on Human Health and Wellness: A Natural Beverage That Boosts Immunity.

Fermented foods have been an important component of the human diet from the time immemorial. It contains a high amount of probiotics that have been associated to a wide range of health benefits, including improved digestion and immunity. This review focuses on the indigenously prepared prebiotic- and probiotic-containing functional fermented rice (named ) by the Ahom Community from Assam, in Northeast India, including all the beneficial and potential effects on human health.

Lymphocyte subsets in the small intestine of piglets fed with probiotic and zinc: a qualitative and quantitative micro-anatomical study.

Background: Piglet mortality is a real concern to the pig farmers. The major cause is due to the late maturation of the immune system and dietary changes in postweaned piglets. The potential role of probiotic and zinc in the stimulation of the immune system is well established.

A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.

The oligoadenylate synthetase (OAS)-RNase L system is an IFN-inducible antiviral pathway activated by viral infection. Viral double-stranded (ds) RNA activates OAS isoforms that synthesize the second messenger 2-5A, which binds and activates the pseudokinase-endoribonuclease RNase L. In cells, OAS activation is tamped down by ADAR1, an adenosine deaminase that destabilizes dsRNA.

Fabrication of metal incorporated polymer composite: An excellent antibacterial agent.

US Food and Drug Administration (FDA) allowed for direct addition of castor oil for human consumption as food and most recently FDA approved castor oil as over-the-counter (OTC) for laxative drug. The present article highlights the green route phosphorylation of castor oil (COL) via condensation polymerization. Further, the incorporation of metal ions Cu (II)) and Zn (II) into the polymer matrix have been carried out at elevated temperature using catalyst p-toluene sulphonic acid (PTSA).

Sunitinib inhibits RNase L by destabilizing its active dimer conformation.

The pseudokinase (PK) RNase L is a functional ribonuclease and plays important roles in human innate immunity. The ribonuclease activity of RNase L can be regulated by the kinase inhibitor sunitinib. The combined use of oncolytic virus and sunitinib has been shown to exert synergistic effects in anticancer therapy.

Small intestinal mucosal cells in piglets fed with probiotic and zinc: a qualitative and quantitative microanatomical study.

Background: Probiotics and zinc are commonly used and beneficial in pig production. This work aimed to assess the effects of probiotic and zinc on the mucosal cells of the small intestine in respect to digestive capacity and immunity in pre- and post-weaned piglets.

Materials And Methods: Eighteen Large White Yorkshire piglets were divided equally into control and treatment groups.

Management of radicular cyst in deciduous molar: A case report.

Radicular cysts associated with deciduous teeth are very rare. They constitute 0.5-3.

S-benzyldithiocarbazate imine coordinated metal complexes kill Candida albicans by causing cellular apoptosis and necrosis.

Development of new chemotherapeutic agents and strategies are urgently needed to curb and halt the growing menace caused by hard-to-treat microbes. Coordination of metals to bioactive organic ligands is now considered to be an efficient strategy for delivering bioactive compounds inside the microbial cell membranes. Metal complexes have been effectively used to treat many dreadful diseases were other treatment modalities had failed.

Graphitic carbon nitride decorated with FeNi nanoparticles for flexible planar micro-supercapacitor with ultrahigh energy density and quantum storage capacity.

Portable miniaturized energy storage micro-supercapacitors have attracted significant attention due to their power source and energy storage capacity, replacing batteries in ultra-small electronic devices. Fabrication with porous and 2D graphitic nanomaterials with high conductivity and surface area leads to high-performance micro-supercapacitors. In order to satisfy the fast-growing energy demands for the next generation, we report performance and design of a 2D heterostructured EDLC (g-CN) and pseudocapacitor (FeNi) resulting in short ionic diffusion path and prominent charge storage based on synergic functionalities.