Publications by authors named "Talia Rose Hubble"
Background: General anesthesia during pregnancy is not uncommon, for example, for trauma surgery, cerclage, or cesarean delivery. Current recommendations are to maintain maternal partial pressure of carbon dioxide in arterial blood (paCO2) at 30 mm Hg, which is based solely on the average maternal paCO2 in awake pregnant women. However, there is no evidence that this target, compared to other targets, would enable optimal conditions for the fetus during general anesthesia.
View Article and Find Full Text PDFEarly antenatal risk factors for births before arrival: An unmatched case-control study.
Acta Obstet Gynecol Scand
February 2024
Introduction: Birth before arrival is associated with maternal morbidity and neonatal morbidity and mortality. Yet, timely risk stratification remains challenging. Our objective was to identify risk factors for birth before arrival which may be determined at the first antenatal appointment.
View Article and Find Full Text PDFIntroduction and history of anaesthesia-induced neurotoxicity and overview of animal models.
Best Pract Res Clin Anaesthesiol
March 2023
Article Synopsis
- Brain development starts at about 3 weeks of pregnancy and continues to refine until around age 20, with the most significant weight gain in the brain occurring at birth.
- Exposure to general anaesthesia, either before or after birth, can disrupt neuronal firing and may harm brain development, a condition known as "anaesthesia-induced neurotoxicity."
- The article reviews research on this topic from 1999 to present, discussing the mechanisms of neurotoxicity and comparing various animal models used in preclinical studies.
Preclinical evidence for anaesthesia-induced neurotoxicity.
Best Pract Res Clin Anaesthesiol
March 2023
Preclinical research concerning anaesthesia-induced neurotoxicity was initiated in 1999. A decade later, the earliest clinical observational data showed mixed results in neurodevelopmental outcomes following anaesthesia exposure at a young age. Hence to date, preclinical studies remain the cornerstone of research in this field, primarily because of the vulnerability of clinical observational studies to confounding bias.
View Article and Find Full Text PDFArticle Synopsis
- Premature infants often suffer from respiratory distress and may need assisted ventilation, which can harm their lungs; CPAP is a noninvasive ventilation method used to mitigate this risk.* -
- A systematic review identified 21 animal studies that explored the effects of CPAP on lung function and structure, revealing that CPAP is less damaging than mechanical ventilation and aids in better gas exchange.* -
- While CPAP shows multiple benefits, including improved outcomes when combined with surfactant treatment, there are concerns about its potential to increase airway reactivity.*
Objective: Digital images might contribute to stigma associated with mental disorders. The aim of this study was to investigate whether these images accurately represent pediatric mental disorders, as well as to explore specific image-related factors that influence perception.
Methods: Four hundred pictures were retrieved from three stock photograph websites ('Shutterstock', 'iStock' and 'Adobe') and 'Google Images' for mental disorders (ADHD, ASD, and depression) and somatic diseases (asthma, diabetes, and influenza) in childhood.