Publications by authors named "Talia M Saal"
Article Synopsis
- The study examines how variations in tumor microenvironments (TMEs) affect cancer progression by analyzing 52 head and neck squamous cell carcinomas.
- It identifies macrophage polarity—determined by CS expression—as a significant factor for prognosis, rather than traditional M1 and M2 classifications.
- The findings indicate that TMEs create organized networks of pro- and antitumor responses, emphasizing that CS macrophage polarity could simplify understanding complex cancer behaviors across different types of tumors.
Diagnosing salivary gland tumors (SGTs) through fine-needle aspiration (FNA) biopsies is challenging due to the overlapping cytomorphologic features between benign and malignant tumors. The authors developed an innovative, multiplexed cycling technology for the rapid analyses of single cells obtained from FNA that can facilitate the molecular analyses and diagnosis of SGTs. Antibodies against 29 protein markers associated with 7 SGT subtypes were validated and chemically modified via custom linker-bio-orthogonal probes (FAST).
View Article and Find Full Text PDFViruses are the second leading cause of cancer worldwide, and human papillomavirus (HPV)-associated head and neck cancers are increasing in incidence in the United States. HPV preferentially infects the crypts of the tonsils rather than the surface epithelium. The present study sought to characterize the unique microenvironment within the crypts to better understand the viral tropism of HPV to a lymphoid-rich organ.
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