Publications by authors named "Talia E Gileadi"
The histone lysine demethylase KDM5B is implicated in recessive intellectual disability disorders, and heterozygous, protein-truncating variants in are associated with reduced cognitive function in the population. The KDM5 family of lysine demethylases has developmental and homeostatic functions in the brain, some of which appear to be independent of lysine demethylase activity. To determine the functions of KDM5B in hippocampus-dependent learning and memory, we first studied male and female mice homozygous for a allele that lacks demethylase activity.
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- TCDD is a toxic environmental pollutant linked to cognitive deficits and autism traits in children; most studies examine acute exposure, unlike typical human exposure.
- The study established a low-dose dietary TCDD exposure in pregnant mice to assess its effects on offspring's behavior, neurodevelopment, and gene expression.
- Results showed subtle motor coordination deficits and brain structure changes in TCDD-exposed females, along with significant gene expression alterations related to neuronal function and development.