Exact solutions via Prabhakar fractional approach to investigate heat transfer and flow features of hybrid nanofluid subject to shape and slip effects.

The core devotion of this study is to develop a generalized model by means of a recently proposed fractional technique in order to anticipate the enhancement in the thermal efficiency of engine oil because of the dispersion of graphene and magnesia nanoparticles. In addition to investigating the synergistic attributes of the foregoing particles, this work evaluates shape impacts for column, brick, tetrahedron, blade, and lamina-like shapes. In the primary model, the flow equation is coupled with concentration and energy functions.

EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression.

Triple-negative breast cancers (TNBCs) are frequently poorly differentiated with high propensity for metastasis. Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase of polycomb repressive complex 2 that mediates transcriptional repression in normal cells and in cancer through H3K27me3. However, H3K27me3-independent non-canonical functions of EZH2 are incompletely understood.

Using a Deep Learning Model to Explore the Impact of Clinical Data on COVID-19 Diagnosis Using Chest X-ray.

The coronavirus pandemic (COVID-19) is disrupting the entire world; its rapid global spread threatens to affect millions of people. Accurate and timely diagnosis of COVID-19 is essential to control the spread and alleviate risk. Due to the promising results achieved by integrating machine learning (ML), particularly deep learning (DL), in automating the multiple disease diagnosis process.

A Generic Approach for Classification of Psychological Disorders Diagnosis using EEG.

Electroencephalogram (EEG) is a widely used technique to diagnose psychological disorders. Until now, most of the studies focused on the diagnosis of a particular psychological disorder using EEG. We propose a generic approach to diagnose the different type of psychological disorders with high accuracy.

Significance of Shape Factor in Heat Transfer Performance of Molybdenum-Disulfide Nanofluid in Multiple Flow Situations; A Comparative Fractional Study.

In this modern era, nanofluids are considered one of the advanced kinds of heat transferring fluids due to their enhanced thermal features. The present study is conducted to investigate that how the suspension of molybdenum-disulfide (MoS2) nanoparticles boosts the thermal performance of a Casson-type fluid. Sodium alginate (NaAlg) based nanofluid is contained inside a vertical channel of width and it exhibits a flow due to the movement of the left wall.

Unsteady MHD natural convection flow of Casson fluid incorporating thermal radiative flux and heat injection/suction mechanism under variable wall conditions.

Unsteady magnetohydrodynamic flow of Casson fluid over an infinite vertical plate is examined under ramped temperature and velocity conditions at the wall. Thermal radiation flux and heat injection/suction terms are also incorporated in the energy equation. The electrically conducting fluid is flowing through a porous material and these phenomena are governed by partial differential equations.

Heat Transfer Enhancement in Unsteady MHD Natural Convective Flow of CNTs Oldroyd-B Nanofluid under Ramped Wall Velocity and Ramped Wall Temperature.

This article analyzes heat transfer enhancement in incompressible time dependent magnetohydrodynamic (MHD) convective flow of Oldroyd-B nanofluid with carbon nanotubes (CNTs). Single wall carbon nanotubes (SWCNTs) and multi-wall carbon nanotubes (MWCNTs) are immersed in a base fluid named Sodium alginate. The flow is restricted to an infinite vertical plate saturated in a porous material incorporating the generalized Darcy's law and heat suction/injection.

An exact analysis of unsteady MHD free convection flow of some nanofluids with ramped wall velocity and ramped wall temperature accounting heat radiation and injection/consumption.

This article investigates the influence of ramped wall velocity and ramped wall temperature on time dependent, magnetohydrodynamic (MHD) natural convection flow of some nanofluids close to an infinitely long vertical plate nested in porous medium. Combination of water as base fluid and three types of nanoparticles named as copper, titanium dioxide and aluminum oxide is taken into account. Impacts of non linear thermal radiation flux and heat injection/consumption are also evaluated.

Next-generation sequencing identifies recurrent copy number variations in invasive breast carcinomas from Ghana.

African and African-American (AA) women have higher incidence of triple-negative breast cancers (TNBC) with high histological grade and aggressive clinical behavior, but the reasons are not fully understood. We recently found that the oncogenic protein EZH2 is overexpressed in Ghanaian breast cancer patients, with 16% of the tumors expressing cytoplasmic EZH2. Understanding the molecular underpinnings of these aggressive tumors may lead to the identification of potential targetable oncogenic drivers.

Unsteady Radiative Natural Convective MHD Nanofluid Flow Past a Porous Moving Vertical Plate with Heat Source/Sink.

In this research article, we investigated a comprehensive analysis of time-dependent free convection electrically and thermally conducted water-based nanofluid flow containing Copper and Titanium oxide (Cu and TiO 2 ) past a moving porous vertical plate. A uniform transverse magnetic field is imposed perpendicular to the flow direction. Thermal radiation and heat sink terms are included in the energy equation.

Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer.

Twenty percent of breast cancer (BC) patients develop distant metastasis for which there is no cure. Mesenchymal stem/stromal cells (MSCs) in the tumor microenvironment were shown to stimulate metastasis, but the mechanisms are unclear. Here, we identified and quantified cancer cells engulfing stromal cells in clinical samples of BC metastasis by dual immunostaining for EZH2 and ALDH1 expression.

p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis.

Overexpression of EZH2 in estrogen receptor negative (ER-) breast cancer promotes metastasis. EZH2 has been mainly studied as the catalytic component of the Polycomb Repressive Complex 2 (PRC2) that mediates gene repression by trimethylating histone H3 at lysine 27 (H3K27me3). However, how EZH2 drives metastasis despite the low H3K27me3 levels observed in ER- breast cancer is unknown.

Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth.

Increased collagen deposition by breast cancer (BC)-associated mesenchymal stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are unknown. Here, we report that the collagen receptor discoidin domain receptor 2 (DDR2) is essential for stromal-BC communication. In human BC metastasis, DDR2 is concordantly upregulated in metastatic cancer and multipotent mesenchymal stromal cells.

Pazopanib inhibits the activation of PDGFRβ-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells.

Brain metastases occur in more than one-third of metastatic breast cancer patients whose tumors overexpress HER2 or are triple negative. Brain colonization of cancer cells occurs in a unique environment, containing microglia, oligodendrocytes, astrocytes, and neurons. Although a neuroinflammatory response has been documented in brain metastasis, its contribution to cancer progression and therapy remains poorly understood.

Tissue-based identification of stem cells and epithelial-to-mesenchymal transition in breast cancer.

Pathologists have recognized breast cancer heterogeneity for decades, but its causes were unknown. In recent years, basic science and translational studies have demonstrated that cancer stem cells contribute to the heterogeneous histologic and functional characteristics of breast cancer. Even more recently, the ability of breast epithelial cells to undergo an epithelial-to-mesenchymal transition has been linked to the acquisition of stem cells properties and enhanced tumor invasion, metastasis, and resistance to available treatments.

Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.

Melanoma differentiation associated gene-9 (MDA-9), also known as syntenin, functions as a positive regulator of melanoma progression and metastasis. In contrast, the Raf kinase inhibitor, RKIP, a negative modulator of RAF-stimulated MEKK activation, is strongly downregulated in metastatic melanoma cells. In this study, we explored a hypothesized inverse relationship between MDA-9 and RKIP in melanoma.

Regulation of RKIP function by Helicobacter pylori in gastric cancer.

Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped bacterium that infects more than half of the world's population and is a major cause of gastric adenocarcinoma. The mechanisms that link H.

TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells.

Brain metastases of breast and other cancers remain resistant to chemotherapeutic regimens that are effective systemically, in part due to the blood-brain barrier. We report that TPI-287, a new microtubule-stabilizing agent, displays in vitro cytotoxic activity similar to taxanes and epothilones. Unlike the taxanes, TPI-287 is permeable through the blood-brain barrier.

The B-Raf status of tumor cells may be a significant determinant of both antitumor and anti-angiogenic effects of pazopanib in xenograft tumor models.

Pazopanib is an FDA approved Vascular Endothelial Growth Factor Receptor inhibitor. We previously reported that it also inhibits tumor cell B-Raf activity in an experimental brain metastatic setting. Here, we determine the effects of different B-Raf genotypes on pazopanib efficacy, in terms of primary tumor growth and anti-angiogenesis.