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Publications by authors named "Talgat Omarov"

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The Oxidative Drug Combination for Suppressing KRAS G12D Inducible Tumour Growth.
Dinara Begimbetova Assiya Kukanova Fatima Fazyl Kenzhekyz Manekenova Talgat Omarov

Biomed Res Int

January 2023

Background: Kirsten rat sarcoma (KRAS) protein is an essential contributor to the development of pancreatic ductal adenocarcinoma (PDAC). KRAS G12D and G12V mutant tumours are significant challenges in cancer therapy due to high resistance to the treatment.

Objective: To determine how effective is the ATO/D-VC combination in suppression of PDAC the mouse transgenic model.

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Synopsis of recent research by authors named "Talgat Omarov"

  • - Talgat Omarov's recent research focuses on the challenges posed by KRAS mutant tumors, specifically targeting the KRAS G12D variant, which is a significant contributor to the development of pancreatic ductal adenocarcinoma (PDAC).
  • - In his 2023 article published in *Biomed Res Int*, Omarov investigates the effectiveness of a combination treatment of arsenic trioxide (ATO) and Vitamin C (D-VC) in suppressing tumor growth in a mouse transgenic model.
  • - The research aims to provide insights into alternative therapeutic strategies to overcome the high resistance of KRAS mutant tumors, offering potential advancements in cancer treatment methodologies.

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