THE PROGNOSTIC UTILITY OF LEUKOCYTE AND PLATELET COUNTS FOR RISK ASSESSMENT OF IN-HOSPITAL COMPLICATIONS IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION.

Objective: The aim: We have aimed to develop method of risk assessment in patients with acute STEMI using blood cells count useful in everyday clinical practice.

Patients And Methods: Materials and methods: 317 STEMI patients admitted to ICCU starting at 01/2014 to 06/2020 were included in this study. Data were evaluated partially retrospectively (n=214), 1st group) and prospectively, applying new risk-assessment tool in 103 patients 2nd group).

[Character and mechanisms of changes in vascular wall reactivity in prolonged hypercholesterolemia].

Changes in the structure and functional properties of the vascular wall after 8 months of alimentary hypercholesterolemia (HCE) were studied. The experiments were conducted on the circular bands of the arch of the aorta in rabbits. Sharp inhibition of the reactivity of the vascular bands was established, which was associated first of all with thickening of the intima due to the development of fibro-atheromatous changes in it.

[Efficacy of vascular wall protection from atherosclerotic damage using various calcium antagonists].

The authors studied the effect of various calcium antagonists--verapamil (VP) and Mg2+ (MgCl2) on the character of affection of the vascular wall ulcer conditions of prolonged hypercholesterolemia (HCE). The blood cholesterol (CS) content increased by the end of the 8th month of HCE to eight-fold the value in intact animals. The specific atherosclerotic changes in this case occupied approximately 80% of the area of the thoracic aorta whose functional properties changed essentially.

[Functional state and adrenergic reactivity of the myocardium in experimental atherosclerosis].

The authors studied the changes in the functional properties of a rabbit heart in protracted alimentary hypercholesterolemia (HCE). It is shown that HCE has a little effect on the characteristics of myocardial contractility and adrenergic sensitivity. In protracted HCE the probability of the occurrence of a myocardial own rhythm in response to the effect of isoprenaline increased.

[The dynamic changes in the functional characteristics of the vascular endothelium and smooth muscle cells under conditions of long-term hypercholesterolemia].

The course of the rabbit aortic wall reactivity changes due to hypercholesterolemia involved, in the first place, the inhibition of the endothelium relaxing influence on the smooth muscle contractile activity and an increase in the muscle sensitivity to neurogenic and humoral tonic influences. Later, a sharp inhibition of the vessel's wall functional activity occurred due to a mechanical factor: the development of connective tissue which prevents active vascular reactions. Nevertheless, endothelial and smooth muscle cells functional activity was high enough.

[Effects of hypercholesterolemia on the electrical and contractile properties of the blood vessel wall].

The investigations were performed on the ring strips of rabbit aorta. The electrical activity of the vessels smooth muscle cells was registered by the "sucrose gap" method; the contractile activity of the strips was determined simultaneously. Experimental atherosclerosis was induced by keeping rabbits on a special diet enriched by cholesterol for 2 and 4 months.

[Ionic mechanisms of endothelium-dependent relaxation of vascular smooth muscle under the action of acetylcholine].

Acetylcholine and nitroglycerin were shown to induce relaxation in muscles of the ring vascular segments of canine coronary arteries and rabbit aortic archs, the magnitude of the reaction depending on the level of initial tonic tension. Methylene blue abolished the relaxation. Mechanical removal of endothelium abolished the reaction to acetylcholine but not to nitroglycerin.