Publications by authors named "Tala Alsharaeh"
Article Synopsis
- Targeting interleukin-23 (IL-23) is a promising treatment for ulcerative colitis (UC), with a focus on two types of inhibitors: IL-23p19 and IL-12/23p40.
- A systematic review of trials found that these inhibitors significantly improve clinical remission, endoscopic remission, and histologic remission in patients with moderate-to-severe UC.
- Additionally, targeting IL-23 showed a reduced risk of adverse events compared to placebo, suggesting that it is both effective and safe for managing UC.
Introduction: Esophageal Stents are used to maintain esophageal lumen patency in esophageal strictures caused by intrinsic and/or extrinsic malignancies and the occlusion of concomitant esophageal fistulas. While data on the efficacy and safety of esophageal stents exist, comprehensive evaluation of adverse events is limited. The aim of this study is to investigate the reported adverse events and device failures associated with esophageal self-expandable metal stents (SEMS) using the FDA's Manufacturer and User Facility Device Experience (MAUDE) database.
View Article and Find Full Text PDFIntroduction: Pancreatic duct stents (PDS) are widely used for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. However, there is a paucity of data regarding the adverse events associated with PDS placement. This study aims to investigate the reported adverse events and device failures related to PDS, utilizing the Manufacturer and User Facility Device Experience (MAUDE) database maintained by the U.
View Article and Find Full Text PDFBackground Cisplatin, a widely used chemotherapeutic agent, offers therapeutic benefits for cancer treatment but often leads to adverse effects on neurogenesis and oxidative stress, causing cognitive impairment. Concurrent physical activity has been proposed as a potential strategy to counteract these side effects. This study aimed to investigate the impact of physical exercise on cisplatin-induced cognitive impairment in a mouse model.
View Article and Find Full Text PDFArticle Synopsis
- A gastrointestinal variant of Lemierre's syndrome (LS), linked to Fusobacterium species, can lead to serious complications like pylephlebitis and liver abscesses, which are becoming increasingly recognized in medical literature.
- A systematic review of 36 patients showed that the majority were middle-aged men with symptoms like fever and abdominal pain, and common findings included portal vein thrombosis and liver abscesses.
- Effective treatment often involves antibiotics, abscess drainage, and long-term anticoagulation, with no reported deaths in the studied cases, emphasizing the importance of timely diagnosis and management.