in C3H/HeN mice: A model for studying pathogen-host interactions.

An infection with the tick-borne has been associated with a broad spectrum of clinical manifestations in humans, but patients are only seldomly reported. Understanding its disease etiology necessitates well-stablished infection models, improving to recognize and diagnose patients with infection and facilitating the development of effective control strategies. In this study, we used C3H/HeN mice as a model to establish infection, achieving a high infection prevalence (89-100 %).

Technical Evaluation of qPCR Multiplex Assays for the Detection of -Borne Pathogens.

Background: The extent to which infections with -borne pathogens (TBPs), other than s. l. and tick-borne encephalitis virus (TBEV), cause disease in humans remains unclear.

Assembly and Comparison of Neoehrlichia mikurensis Genomes.

Neoehrlichia mikurensis is widely prevalent in across Europe and has been associated with human disease. However, diagnostic modalities are limited, and much is still unknown about its biology. Here, we present the first complete Neoehrlichia mikurensis genomes directly derived from wildlife reservoir host tissues, using both long- and short-read sequencing technologies.

Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens.

Background: The impact of infections with tick-borne pathogens (TBPs) other than Borrelia burgdorferi (s.l.) and tick-borne encephalitis virus (TBEV) on public health in Europe remains unclear.

Circulation of Species and Their Exposure to Humans through .

Human babesiosis in Europe has been attributed to infection with and, to a lesser extent, with and which are all transmitted to humans through a bite of . These species circulate in the Netherlands, but autochthonous human babesiosis cases have not been reported so far. To gain more insight into the natural sources of these species, their presence in reservoir hosts and in was examined.

Evaluation of Disease Causality of Rare -Borne Infections in Europe.

In Europe, ticks transmit pathogens such as sensu lato and tick-borne encephalitis virus (TBEV). In addition, there is evidence for transmission to humans from of , , , , and . However, whether infection with these potential tick-borne pathogens results in human disease has not been fully demonstrated for all of these tick-borne microorganisms.

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission.

Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors for some of the most frequently occurring human tick-borne diseases, particularly Lyme borreliosis and tick-borne encephalitis virus (TBEV). The search for vaccines against these diseases is ongoing.

Control of Lyme borreliosis and other Ixodes ricinus-borne diseases.

Lyme borreliosis (LB) and other Ixodes ricinus-borne diseases (TBDs) are diseases that emerge from interactions of humans and domestic animals with infected ticks in nature. Nature, environmental and health policies at (inter)national and local levels affect the risk, disease burden and costs of TBDs. Knowledge on ticks, their pathogens and the diseases they cause have been increasing, and resulted in the discovery of a diversity of control options, which often are not highly effective on their own.

Francisella-Like Endosymbionts and Rickettsia Species in Local and Imported Hyalomma Ticks.

ticks (Acari: Ixodidae) are hosts for -like endosymbionts (FLE) and may serve as vectors of zoonotic disease agents. This study aimed to provide an initial characterization of the interaction between and FLE and to determine the prevalence of pathogenic in these ticks. , , , , and ticks, identified morphologically and molecularly, were collected from different hosts and locations representing the distribution of the genus in Israel, as well as from migratory birds.