Prediction of tissue-of-origin of early stage cancers using serum miRNomes.

Background: Noninvasive detection of early stage cancers with accurate prediction of tumor tissue-of-origin could improve patient prognosis. Because miRNA profiles differ between organs, circulating miRNomics represent a promising method for early detection of cancers, but this has not been shown conclusively.

Methods: A serum miRNA profile (miRNomes)-based classifier was evaluated for its ability to discriminate cancer types using advanced machine learning.

Evaluation of polarized terahertz waves generated by Cherenkov phase matching.

We report terahertz (THz) wave generation by satisfying Cherenkov phase-matching condition in both s and p polarizations. A dual-wavelength optical parametric oscillator is constructed from two potassium titanium oxide phosphate crystals pumped by a frequency-doubled Nd:YAG laser. By rotating the orientation of both a lithium niobate crystal (LiNbO3) and the polarization of the pump waves, the polarization of the THz wave changes.

Broadband THz-wave generation by satisfying the noncollinear phase-matching condition with a reflected signal beam.

We demonstrated broadband terahertz (THz) wave generation by satisfying the noncollinear phase-matching condition with a reflected signal beam. We constructed a dual-wavelength optical parametric oscillator with two potassium titanium oxide phosphate crystals pumped by a frequency-doubled Nd:YAG laser. The collinear pump and signal waves were irradiated into a lithium niobate crystal.

THz-wave sensing via pump and signal wave detection interacted with evanescent THz waves.

We report a novel sensing technique that uses an evanescent terahertz (THz) wave, without detecting the THz wave directly. When a THz wave generated by Cherenkov phase matching via difference frequency generation undergoes total internal reflection, the evanescent THz wave is subject to a phase change and an amplitude decrease. The reflected THz wave, under the influence of the sample, interferes with the propagating THz wave and the changing electric field of the THz wave interacts with the electric field of the pump waves.

Cherenkov phase matched THz-wave generation with surfing configuration for bulk lithium nobate crystal.

We demonstrated a Cherenkov phase matched THz-wave generation with surfing configuration for bulk lithium niobate crystal. THz-wave output was enhanced about 50 times by suppressing phase mismatching for THz-wave propagation direction. The suppression was achieved by combining two pumping waves with dual wavelength with finite angle, and THz-frequency was controllable by changing the angle within 2.

Extremely frequency-widened terahertz wave generation using Cherenkov-type radiation.

Terahertz (THz) wave generation based on nonlinear frequency conversion is promising way for realizing a tunable monochromatic bright THz-wave source. Such a development of efficient and wide tunable THz-wave source depends on discovery of novel brilliant nonlinear crystal. Important factors of a nonlinear crystal for THz-wave generation are, 1.

Cherenkov phase-matched monochromatic THzwave generation using difference frequency generation with a lithium niobate crystal.

We demonstrated a Cherenkov phase-matching method for monochromatic THz-wave generation using the difference frequency generation process with a lithium niobate crystal, which resulted in high conversion efficiency and wide tunability. We successfully generated monochromatic THz waves across the range 0.2-3.