Publications by authors named "Takuya Akaji"
Front Microbiol
April 2020
Article Synopsis
- Nosocomial infections caused by multidrug-resistant bacteria pose significant health risks, with colistin being a key treatment targeting lipopolysaccharides (LPS).
- However, these bacteria can develop resistance to colistin by losing their LPS, which affects their virulence and interaction with host immune cells.
- Research shows that neutrophils can still effectively kill LPS-deficient strains of bacteria, primarily using the enzyme lysozyme, offering insights for developing therapies against drug-resistant infections, especially in immunocompromised patients.
