Publications by authors named "Takushi Manabe"
Article Synopsis
- Portal vein thrombosis (PVT) can worsen the prognosis for patients with cirrhosis, and the study explored the effectiveness of edoxaban compared to warfarin for treating PVT.
- The results showed that edoxaban had a significantly higher overall response rate (76.7%) in improving PVT compared to warfarin (29.4%) and allowed for long-term recanalization without harmful effects on liver function.
- Edoxaban is easy to initiate, making it a promising option for outpatient treatment of PVT, providing patients with better outcomes than traditional warfarin therapy.
Article Synopsis
- Hepatocellular carcinoma (HCC) is becoming more common in patients with autoimmune hepatitis (AIH) as life expectancy improves, but its impact on overall prognosis and treatment options remains unclear.
- A study of 131 AIH patients revealed that while liver failure was a leading cause of death initially, deaths from HCC increased over time; factors like cirrhosis at diagnosis significantly raised the risk of developing HCC.
- Current treatments for HCC in AIH patients are limited, and early detection is crucial for improving outcomes.
Although there have been advances in the prevention and diagnosis of hepatocellular carcinoma (HCC) in recent years, many HCC patients are still diagnosed with advanced stage. Systemic therapy is indicated for unresectable HCC (uHCC) with major vascular invasion and/or extrahepatic metastases, and the atezolizumab plus bevacizumab (atezo/bev) combination is currently recommended as first-line treatment for uHCC. Recently, sarcopenia-related factors, including decreased skeletal muscle index (SMI), have been reportedly associated with prognosis in uHCC patients treated with sorafenib or lenvatinib.
View Article and Find Full Text PDFComputed tomography (CT) is often used in the diagnosis of sarcopenia. In this study, we validated the assessment of sarcopenia by the psoas muscle volume using versatile software. The study involved a retrospective analysis of data from 190 patients with liver disease who underwent grip-strength testing and abdominal pelvic computed tomography.
View Article and Find Full Text PDFSarcopenia-related factors, including the skeletal muscle index (SMI), are reportedly associated with prognosis in patients with hepatocellular carcinoma (HCC) receiving various treatments. However, there is no evidence relating to hepatic arterial infusion chemotherapy (HAIC). In this study, we investigated whether a low SMI was associated with worse clinical outcomes of HAIC.
View Article and Find Full Text PDFA patient with genotype 1b chronic hepatitis C virus who had been treated with pegylated interferon and ribavirin (RBV) was treated with glecaprevir/pibrentasvir (GLE/PIB) for 12 weeks. A sustained virological response at post-treatment week 12 (SVR12) was achieved, but relapse occurred approximately 31 weeks after the end of treatment. The patient had a history of allergy to RBV and was treated with ledipasvir/sofosbuvir (LDV/SOF), achieving SVR12 and remaining hepatitis C virus-negative until 24 weeks after the completion of treatment.
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