Publications by authors named "Takumu Watanabe"
Development of in-situ Raman diagnosis technique of eosinophil esophagitis.
Spectrochim Acta A Mol Biomol Spectrosc
January 2023
Article Synopsis
- The study investigates the use of Raman spectroscopy with 633 nm and 785 nm excitation light to detect eosinophil accumulation in live esophageal tissue, finding weak signals from hemoglobin with 785 nm but strong resonance effects from eosinophil peroxidase (EPO) with 633 nm.
- A specific optical probe called BHRP, featuring a sapphire ball lens, was utilized for measuring the Raman spectra of eosinophils in mouse tissue, indicating enhanced detection capabilities.
- Principal component analysis (PCA) successfully differentiated eosinophils from other blood cells in the spectral data, demonstrating the effectiveness of 785 nm Raman spectroscopy for diagnosing eosinophilic esoph
The term "peptoids" was introduced decades ago to describe peptide analogues that exhibit better physicochemical and pharmacokinetic properties than peptides. Oligo(-substituted glycine) (oligo-NSG) was previously proposed as a peptoid due to its high proteolytic resistance and membrane permeability. However, oligo-NSG is conformationally flexible, and ensuring a defined shape in water is difficult.
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