Relative stereochemical determination of the C61-C83 fragment of symbiodinolide using a stereodivergent synthetic approach.

Structural determination is required in the use of marine natural products to create novel drugs and drug leads in medicinal chemistry. Symbiodinolide, which is a polyol marine natural product with a molecular weight of 2860, increases the intracellular Ca concentration and exhibits inhibitory activity against cyclooxygenase-1. Seventy percent of the structure of symbiodinolide has been stereochemically clarified.

Meat the challenge: Segmentation and profiling of Japanese beef mince and its substitutes consumers.

Shifts in protein production methods are an emerging challenge toward realizing a sustainable society. This paper aims to examine preferences among Japanese consumers regarding attributes of beef mince and its substitutes, to develop consumer segments based on these preferences, and to explore the segment with higher acceptance of replacement from conventional products. This paper also aims to explain intersegment differences from consumer heterogeneity in human values, scientific literacy, and sociodemographic viewpoints for a deeper understanding of consumer behavior in each segment.

Real-Time Assessment of Causal Attribution Shift and Stay Between Two Successive Tests of Movement Aids.

The development of welfare assistive devices for frail elderly people has attracted significant attention for its effort to improve the quality of life and reduce the burden on caregivers. However, it is challenging to conduct multiple user tests because of the significant burden on the elderly; thus, we need efficient ways to extract insight through different approaches. In this study, we aim to elucidate real-time transitions in users' emotions and achievement motivation while using such a device.

Necessity of two-dimensional visualization of validity in the nanomechanical mapping of atomic force microscopy for sulphur cross-linked rubber.

The importance of the two-dimensional (2D) visualization of validity for nanomechanical mapping in atomic force microscopy (AFM) for sulphur cross-linked rubber is emphasized for accurately interpreting the nanoscale physical properties on the surface of the soft material. The "-factor," evaluated to be the difference between the experimental and theoretical force-deformation curves, was considered to be the reliability index of the AFM analysis for all data points on the sample surface. A small -factor corresponds to high accuracy.

Late-stage divergent synthesis and antifouling activity of geraniol-butenolide hybrid molecules.

Hybrid molecules consisting of geraniol and butenolide were designed and synthesized by the late-stage divergent strategy. In the synthetic route, ring-closing metathesis was utilized for the construction of a butenolide moiety. A biological evaluation of the eight synthetic hybrid compounds revealed that these molecules exhibit antifouling activity against the cypris larvae of the barnacle Balanus (Amphibalanus) amphitrite with EC values of 0.

[Limits of Cognition with Visual Parallax of Stereoscopic Images].

Objectives: Recent advances in three-dimensional (3D) display technology have contributed significantly to society, particularly in the increasing use of stereoscopic characters. For example, 3D text information is utilized in digital signage. However, research on 3D characters is limited and discussion on the safety and comfort of 3D technology is lacking.