Photoredox/Sulfide Dual Catalysis for Modular Synthesis of Multi-Substituted Furan Rings via Catalytic Indirect Reductive Quenching.

The catalytic indirect reductive quenching method is facilitated by a combination of Ir(III) photoredox and sulfide dual-catalysis system. This study demonstrated a method for synthesizing multi-substituted furans by using a photoredox/sulfide dual-catalysis system. This method enables the synthesis of various furan derivatives, including spirofurans and phthalans.

Structure-Activity Relationship Study of CYM51010, an agonist for the µ-δ Opioid Receptor Heterodimer.

Although opioid analgesics are indispensable in treating pain, these drugs are accompanied by life-threatening side effects. While clinically relevant opioid drugs target the µ opioid receptor (MOR), a heterodimer between the MOR and the δ opioid receptor (DOR) has emerged as another target to develop safer analgesics. Although some heterodimer-preferring agonists have been reported so far, it is still difficult to activate the MOR/DOR heterodimer selectively in the presence of MOR or DOR monomers/homodimers.

Author Correction: Violet LED light enhances the recruitment of a thrip predator in open fields.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A New Lead Identification Strategy: Screening an sp -rich and Lead-like Compound Library Composed of 7-Azanorbornane Derivatives.

Although the advantages of sp -rich, sterically complicated molecules in drug development have been pointed out, modern screening libraries are filled with planar, sp -rich components. Compounds that are sp -rich are difficult to synthesize, and thus we aimed to invent an efficient method to construct sp -rich libraries. By modifying sp -rich 7-azanorbornane scaffolds through click chemistry, we efficiently prepared a small set of compounds.

Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator.

Oxytocin (OT) is a 9-amine neuropeptide that plays an essential role in mammalian labor, lactation, maternal bonding, and social affiliation. OT has been reported to exert an analgesic effect in both humans and animals, and the results of certain animal experiments have shown that the analgesic effect of OT is partially blocked by opioid receptor antagonists. To investigate the relationship between OT and μ opioid receptor (MOR), we evaluated how OT affects MOR in vitro by performing an electrical impedance-based receptor biosensor assay (CellKey™ assay), an intracellular cAMP assay, and a competitive receptor-binding analysis by using cells stably expressing human MOR and OT receptor.

Violet LED light enhances the recruitment of a thrip predator in open fields.

The predatory bug Orius sauteri is an indigenous natural enemy of thrips and whiteflies in Asian countries. To put these bugs to practical use in pest management, methods to attract and retain the bugs in agricultural fields are needed. We previously showed that violet light (405 nm) attracts O.