Synopsis of recent research by authors named "Takumi Nemoto"
- Takumi Nemoto's recent research focuses on the molecular mechanisms involved in cholesterol sensing and transport at membrane contact sites between the endoplasmic reticulum and Golgi apparatus.
- In his 2021 study, he demonstrated that the SCAP protein interacts with the VAP-OSBP complex to facilitate the biogenesis of CARTS, which are critical for counter-transporting cholesterol and phosphatidylinositol 4-phosphate (PI4P) at these contact sites.
- The findings indicate that knockdown of SCAP disrupts PI4P turnover and alters the distribution of the VAP-OSBP complex, suggesting SCAP's significant role in maintaining lipid homeostasis in the cell.
