Publications by authors named "Takumi Nakahara"
Article Synopsis
- The text discusses a medical case involving an 80-year-old woman with diabetes who developed a pleural effusion after undergoing surgery for a femoral neck fracture and a toe ulcer.
- The pleural fluid was cultured and revealed infection, prompting treatment with antibiotics cefazolin and clindamycin.
- It highlights that while certain bacteria can cause skin and throat lesions, severe systemic infections are rare, citing that only four instances of pyothorax caused by the specific bacteria have been documented, with none involving bacterial co-infections.
Cyclic naphthalene diimides (cNDIs), with a ferrocene moiety (cFNDs) and different linker lengths between the ferrocene and cNDI moieties, were designed and synthesized as redox-active, tetraplex-DNA ligands. Intramolecular stacking was observed between ferrocene and the NDI planes, which could affect the binding properties for G-quadruplexes. Interestingly, the circular dichroism spectrum of one of these compounds clearly shows new Cotton effects around 320-380 and 240 nm, which can be considered a direct evidence of intramolecular stacking of ferrocene and the NDI.
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