Publications by authors named "Takumi Moriuchi"
Article Synopsis
- - This study analyzed the genotypes of Bordetella pertussis, the bacteria causing whooping cough, in Cambodia using DNA from patients' nasopharyngeal swabs collected between 2008 and 2016.
- - Researchers found that 54% of the samples provided full genetic profiles, identifying eight different MLVA types, with MT27 and MT29 being the most prevalent strains, making up 73% of the total cases.
- - Results indicated that the strains in Cambodia shared similarities with those from developed countries using acellular vaccines, while being distinct from strains found in countries that still use whole-cell vaccines.
In 2013, national serosurveillance detected a high seroprevalence of antibodies to pertussis toxin (PT) from Bordetella pertussis among Japanese adults. Thus, we aimed to determine the cause(s) of this high seroprevalence, and analyzed the titers of antibodies to PT and filamentous hemagglutinin (FHA) among adults (35-44 years old), young children (4-7 years old), and older children (10-14 years old). Our quantitative analyses revealed that adults had higher seroprevalences of anti-PT IgG and PT-neutralizing antibodies, and similar titers of anti-FHA IgG, compared to the young and older children.
View Article and Find Full Text PDFWe evaluated a commercial loop-mediated isothermal amplification (LAMP) assay kit for Bordetella pertussis detection. The LAMP primers were designed to target the ptxP1 allele of the pertussis toxin promoter, but the assay could detect B. pertussis ptxP3 and ptxP8 strains in addition to ptxP1 strains, with high analytical sensitivity.
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