Publications by authors named "Takumi Isobe"
Int J Mol Sci
September 2019
Article Synopsis
- Progesterone is used to mature oocytes in African clawed frogs but doesn't release them from follicle cells, so the study investigates an in vitro method using progesterone and low doses of collagenase.
- Researchers find that both germinal vesicle breakdown (GVBD) and oocyte release occur simultaneously during ovulation, showing the roles of MAPK and MMP pathways.
- The new in vitro model established in the study may enhance understanding of the ovulation process in these frogs.
