Publications by authors named "Takuma Kunieda"
Background: Chronic spontaneous urticaria (CSU) is one of the most intractable human-specific skin diseases. However, as no experimental animal model exists, the mechanism underlying disease pathogenesis in vivo remains unclear, making the establishment of a curative treatment challenging.
Methods: A novel approach combining mathematical modelling, in vitro experiments and clinical data analysis was used to infer the pathological state of CSU patients from geometric features of the skin eruptions.
Article Synopsis
- Chronic spontaneous urticaria (CSU) causes daily itchy hives for over 6 weeks, and its severity is linked to the activation of the extrinsic coagulation system.
- Researchers studied how vascular endothelial cells (HUVECs) respond to sequential stimulation by tissue factor inducers (TFIs) to understand the timing of coagulation activation better.
- Findings revealed that TF expression can be enhanced even when the second TFI is applied up to 22 hours after the first, indicating a prolonged priming effect of TFI that lasts for half a day or more.