Publications by authors named "Takuma Kai"
Article Synopsis
- Human serum albumin (HSA) can enhance the effectiveness of short-lived drugs by extending their presence in the bloodstream when therapeutic agents are conjugated with albumin-binding moieties (ABMs).
- A new method was developed to prepare both HSA domain III and its d-enantiomer, allowing for structural and functional analyses that confirmed their mirror-image properties and ability to be recognized by the neonatal Fc receptor (FcRn).
- The synthetic l-HSA domain III showed similar binding characteristics to the native HSA site II, making the synthetic d-HSA domain III a valuable resource for studying how HSA recognizes molecules at that site.
Nearly half of the human genome consists of repetitive sequences such as long interspersed nuclear elements. The relationship between these repeating sequences and diseases has remained unclear. Gene trapping is a useful technique for disrupting a gene and expressing a reporter gene by using the promoter activity of the gene.
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