Publications by authors named "Takuma Hasegawa"
Iodine-129, which is a promising tracer for dating old groundwater, has been used as a tracer for deep upwelling groundwater. The nuclide is expected to be one of the key factors for site selection for high-level radioactive waste disposal, which is a global societal issue. The pre-anthropogenic I/I ratio for marine iodine is (1.
View Article and Find Full Text PDFFluorescent dyes are commonly used as conservative groundwater tracers to track the migration of water. Over- or underestimation of important parameters such as the water flow rate can occur if the concentration of a dye is changed by unexpected reactions. Because such errors may seriously affect the results of experiments, the reactions and processes that change fluorescent dye concentrations need to be understood.
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- This study investigated the use of the serum creatinine-to-cystatin C ratio to assess muscle mass and strength in individuals with nonalcoholic fatty liver disease (NAFLD) among 641 Japanese adults.
- Results showed that the ratio effectively identified low muscle mass and handgrip strength, with high accuracy metrics (0.84 for low muscle mass in men and 0.96 for low strength).
- Additionally, the ratio significantly correlated with muscle mass index and grip strength but did not relate to the severity of hepatic fat accumulation.
Matrix-assisted laser desorption/ionization-based mass spectrometry imaging (MSI) of separated lipids on thin-layer chromatography (TLC) plates or followed by blotted hydrophilic polyvinylidene fluoride (PVDF) membranes has become a powerful tool in lipidomic analyses. However, background peaks in MS spectra often cover lipid peaks in a low amount/ionization effect; consequently, only low intensities/resolutions MSI are obtained. To address the aforementioned problem, we attempted 1,2-dichloroethane pre-washing of TLC plates before development and found that backgrounds could successfully be removed from the TLC plate or PVDF membrane.
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- The study investigates the relationship between the serum ratio of β-carotene to retinol (SC/SR) and non-alcoholic fatty liver disease (NAFLD) in 606 Japanese adults diagnosed via ultrasonography.
- Women showed higher daily intake of carotenoids and a higher SC/SR ratio than men; however, the SC/SR ratio in women decreased with worsening hepatic steatosis, while it remained constant in men.
- The research indicates that a higher SC/SR ratio may reduce the likelihood of NAFLD, particularly in women, and correlates positively with good cholesterol while negatively with triglycerides.
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- Altered amino acid levels have been linked to nonalcoholic fatty liver disease (NAFLD) and liver fibrosis, but it's unclear if this is due to liver metabolism changes or insulin resistance.
- This study aimed to clarify the relationship between amino acid levels, fatty liver, and liver fibrosis while accounting for insulin resistance.
- It found that although many amino acids differed among groups, only glutamate and glycine remained significant after adjusting for insulin resistance, indicating they are independent risk factors for liver fibrosis.
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- The study explores the connection between osteoporosis and fatty liver disease (FLD) in an aging Japanese community, involving 1,020 participants assessed through health surveys.
- Results showed that while bone mineral density (BMD) levels were similar between individuals with and without FLD, older adults with FLD had lower bone formation and higher bone resorption, indicating potential bone health issues.
- The findings suggest that FLD negatively affects bone metabolism in the elderly, highlighting the need for more research to better understand this relationship and its implications for osteoporosis.
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- * Results showed that those with NAFLD had higher body mass index (BMI), body fat, and a greater L/A ratio compared to healthy individuals, with the L/A ratio increasing alongside steatosis severity.
- * While the L/A ratio was linked to steatosis severity and certain lipid profiles, it did not show a relationship with arterial stiffness (measured by baPWV), suggesting that other factors may influence cardiovascular risk in NAFLD
Background: Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this study involving a large number of participants.
Methods: In total, 1148 adults participated in the health survey.
No templates needed: The title reaction makes it easy to construct the bicyclo[6.3.0]undecadienone framework in high yields (see scheme).
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