Skull Bone Regeneration Using Chitosan⁻Siloxane Porous Hybrids-Long-Term Implantation.

Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds.

Comparison between a novel and conventional artificial pancreas for perioperative glycemic control using a closed-loop system.

This clinical study aimed to compare a novel and conventional artificial pancreas (AP) used in surgical patients for perioperative glycemic control, with respect to usability, blood glucose measurements, and glycemic control characteristics. From July in 2010 to March in 2015, 177 patients underwent perioperative glycemic control using a novel AP. Among them, 166 patients were eligible for inclusion in this study.

A method for deciding the optimal anticoagulant infusion dose for blood purification therapy.

Background: The incidence of iatrogenic pseudoaneurysms has recently increased due to the more frequent use of high doses of anticoagulants in apheresis therapy. The reason why the decision for an appropriate dose of the anticoagulant is difficult is that such information about the material properties of adsorbers is not provided.

Objective: To investigate the calculations to determine the optimal dose of heparin sodium to administer during apheresis.

Preparation of Porous Chitosan-Siloxane Hybrids Coated with Hydroxyapatite Particles.

This paper describes the apatite deposition of chitosan-silicate porous hybrids derived from chitosan and γ-glycidoxypropyltrimethoxysilane (GPTMS) in alkaline phosphate solution. The preparation of porous hybrids with needle-like apatite on their surfaces is described. Following apatite deposition the porous hybrids maintained high porosity.

Perioperative intensive insulin therapy using an artificial endocrine pancreas with closed-loop glycemic control system: the effects of no hypoglycemia.

Background: We examined whether perioperative intensive insulin therapy (IIT) using an artificial pancreas (AP) with a closed-loop glycemic control system can be used to prevent hypoglycemia in surgical patients.

Methods: Between 2006 and 2012, perioperative glycemic control using an AP was performed in 427 patients undergoing general surgery. A total of 305 patients undergoing IIT using an AP in the target blood glucose range of 80 to 110 mg/dL were enrolled in the study.

Blood compatibility of the adsorptive device filled with poly arylate beads.

The clinical treatments with blood purification therapy is most suitable in which a blood compatible adsorbent is employed. In the present study, two kinds of adsorber with different filling ratio (% rate with a bulk volume in the column volume (v)) with 83% (PAB-83) and 100% (PAB-100) were prepared, respectively. The adsorbent (PAB - Poly Arylate Beads), which was filled up in the column, was prepared with the phase-inversion method.

Low density lipoprotein adsorption on sol-gel derived alumina for blood purification therapy.

Among the clinical treatments of Familial Hyper cholesterolemia patients to reduce the concentration of low density lipoprotein (LDL), blood purification therapy is most suitable in which a blood-compatible adsorbent is employed. In the present study, alumina powders were prepared via a sol-gel route to develop a LDL-adsorbent Aluminum tri2-propoxide was hydrolyzed and subsequently calcined up to 1200 degrees C. Surface charge density and pore size distribution were measured, and the phases were identified.

Bilirubin adsorption property of sol-gel-derived titania particles for blood purification therapy.

Titania (anatase) gel powders were prepared by peptizing commercially available titania sols and heating them at temperatures up to 700 degrees C, as candidates for bilirubin adsorbents for blood purification therapy. Those titania particles were in contact with a protein solution containing bilirubin and bovine serum albumin that mimics the blood of bilirubinemia patients. The amount of free or direct bilirubin in the solution insignificant.