[A case of secondary sclerosing cholangitis caused by chemotherapy with nab-paclitaxel].

A 73-year-old woman had received 9 months of chemotherapy with nab-paclitaxel for locally advanced breast cancer. During the treatment, she was well and showed no major side effects except for alopecia and arthralgia. The tumor showed a tendency to reduction.

X-ray absorption spectral studies on the anion-selectivity of a ruthenium(II) polypyridine complex-impregnated polymer ultrathin film.

The anion-selectivity of the surface of a polymer ultrathin film incorporating an amphiphilic ruthenium(II) polypyridine complex with diperchlorate was examined using X-ray absorption spectroscopy with the total electron-yield method. The adsorbed species on the film surface were found to depend on the chemical composition in water where the film was prepared. By combining the X-ray absorption spectra with a molecular-orbital calculation, the molar ratio (MClO4/MRu) between the ClO4- ions and the Ru head group on the film surface could be semi-quantitatively analyzed; it was 0.

Clinical significance of a highly sensitive enzyme immunoassay of hepatitis B surface antigen using a novel electron spin resonance technique.

We developed a highly sensitive enzyme immunoassay (EIA), the p-AP/HHTIO method, that detects serum hepatitis B surface antigen (HBsAg) by measuring stabilized nitroxide radicals using a novel electron spin resonance technique [Matsuo et al. (1998) Free Radic Biol Med 25:929-935]. To demonstrate the clinical significance of this method and to reveal occult hepatitis B virus (HBV) infection in patients, we used the method to analyze serum samples of 30 patients with acute or fulminant hepatitis who were negative for HBsAg by standard EIA, and those of seven chronic HBV carriers who became negative for HBsAg during a follow-up period by standard EIA.