Publications by authors named "Takkinen Hanna-Mari"
Reply to Wei-Zhen Tang, MD; Wei-Ze Xu, MD; and Tai-Hang Liu, PhD.
Pediatr Allergy Immunol
November 2024
Background: Prospective longitudinal evidence considering the entire childhood food consumption in relation to the development of islet autoimmunity (IA or) type 1 diabetes is lacking.
Objectives: We studied the associations of consumption of various foods and their combinations with IA and type 1 diabetes risk.
Methods: Children with genetic susceptibility to type 1 diabetes born in 1996-2004 were followed from birth up to ≤6 y of age in the prospective birth cohort type 1 diabetes prediction and prevention study (n = 5674).
Background: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear.
Methods: We analyzed data from 3176 mother-child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG.
Article Synopsis
- The study aimed to examine the link between maternal gluten and cereal intake during pregnancy and lactation and the risk of type 1 diabetes in children, focusing on a group of 4943 genetically susceptible children from Finland.
- Results showed that maternal gluten intake during pregnancy had no significant association with the development of islet autoimmunity or type 1 diabetes in offspring, while higher barley consumption during lactation was linked to an increased risk of type 1 diabetes.
- The findings suggest that maternal intake of gluten, most cereals, or dietary fiber during pregnancy and lactation does not impact the child's risk for these conditions, except for barley during lactation.
Background: Gut dysbiosis and increased intestinal permeability have been reported to precede type 1 diabetes-related autoimmunity. The role of gut inflammation in autoimmunity is not understood.
Objectives: This study aimed to assess whether gut inflammation markers are associated with risk of islet autoimmunity and whether diet is associated with gut inflammation markers.
Background: Prospective studies investigating the association among fruit, berry, and vegetable consumption and the risk of islet autoimmunity (IA) and type 1 diabetes (T1D) are few.
Objectives: In this cohort study, we explored whether the consumption of fruits, berries, and vegetables is associated with the IA and T1D development in genetically susceptible children.
Methods: Food consumption data in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) cohort study were available from 5674 children born between September 1996 and September 2004 in the Oulu and Tampere University Hospitals.
Background: Fruit and vegetable consumption has been linked to a decreased risk of asthma, but prospective evidence on longitudinal consumption in childhood is scarce. We aimed to investigate the association between fruit and vegetable consumption in childhood and the risk of asthma by the age of 5 years, and to explore the role of processing of fruits and vegetables in the Finnish Type 1 Diabetes Prediction and Prevention Allergy Study.
Methods: Child's food consumption was assessed by 3-day food records completed at the age of 3 and 6 months, and 1, 2, 3, 4, and 5 years, and asthma and allergies by a validated modified version of the ISAAC questionnaire at the age of 5 years.
The current definition of dietary fibre was adopted by the Codex Alimentarius Commission in 2009, but implementation requires updating food composition databases with values based on appropriate analysis methods. Previous data on population intakes of dietary fibre fractions are sparse. We studied the intake and sources of total dietary fibre (TDF) and dietary fibre fractions insoluble dietary fibre (IDF), dietary fibre soluble in water but insoluble in 76 % aqueous ethanol (SDFP) and dietary fibre soluble in water and soluble in 76 % aqueous ethanol (SDFS) in Finnish children based on new CODEX-compliant values of the Finnish National Food Composition Database Fineli.
View Article and Find Full Text PDFPurpose: The aim was to study the associations between dietary intake of fatty acids in childhood and the risk of islet autoimmunity and type 1 diabetes (T1D).
Methods: The prospective Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study included children with genetic susceptibility to T1D born between 1996 and 2004. Participants were followed up every 3 to 12 months up to 6 years for diet, islet autoantibodies, and T1D.
Article Synopsis
- Cows' milk allergy (CMA) is a common early allergic condition, potentially influenced by dietary factors during pregnancy.
- The study examined whether the types of fatty acids consumed by mothers during pregnancy affect the likelihood of their children developing CMA.
- Results indicated that while most fatty acid intake wasn't linked to CMA risk, higher intake of alpha-linolenic acid correlated with a lower risk of CMA in children of mothers without allergic rhinitis or asthma histories.
Article Synopsis
- The study examined how maternal vitamin C and iron intake during pregnancy might influence the risk of children developing islet autoimmunity and type 1 diabetes.
- It included a cohort of 4,879 mothers and their children from Finland, focusing on diets assessed late in pregnancy through a food frequency questionnaire.
- The results showed no significant link between the intake of these nutrients, whether from food or supplements, and the risk of islet autoimmunity or type 1 diabetes in the offspring.
Article Synopsis
- - Cows' milk allergy (CMA) is the most common food allergy in kids, often linked to other atopic diseases, and may be influenced by factors like maternal diet during pregnancy, though evidence is unclear.
- - A study explored the link between what pregnant mothers eat, specifically antioxidant nutrients, and the development of CMA in their children by analyzing dietary data from 4,403 children in Finland.
- - The results indicated that higher maternal intake of β-carotene was associated with a greater risk of CMA in kids, suggesting that taking antioxidant supplements may not offer extra protection beyond a regular diet.
Article Synopsis
- High dietary intake of nitrate and nitrite during pregnancy was studied to see if it affects the risk of type 1 diabetes in children.
- The study followed 4,879 children in Finland with increased genetic risk for 15 years, monitoring islet autoimmunity and diabetes development.
- Results showed no significant association between maternal nitrate or nitrite consumption and the risk of islet autoimmunity or type 1 diabetes in the offspring.
Article Synopsis
- The study followed 6081 children at risk for type 1 diabetes to investigate if the processing of cows' milk affects the development of islet autoimmunity.
- By age 6, 246 children developed islet autoimmunity, with both non-fermented and fermented milk products linked to a higher risk.
- No specific processing method (like homogenization or heat treatment) was identified as a significant risk factor, reinforcing the idea that high milk consumption could increase islet autoimmunity in genetically susceptible kids.
Background: Synergistic role of exposure to cats, dogs, and farm animals during infancy on the risk of childhood asthma and allergy remains unknown.
Objectives: To investigate independent and synergistic associations between exposure to indoor pets and farm animals during infancy and the risk of asthma and allergy by age 5.
Methods: We studied 3781 children participating in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study.
Importance: Dietary proteins, such as gluten, have been suggested as triggers of the disease process in type 1 diabetes (T1D).
Objective: To study the associations of cereal, gluten, and dietary fiber intake with the development of islet autoimmunity (IA) and T1D.
Design, Setting, And Participants: The prospective birth cohort Finnish Type 1 Diabetes Prediction and Prevention Study recruited children with genetic susceptibility to type 1 diabetes from September 1996 to September 2004 from 2 university hospitals in Finland and followed up every 3 to 12 months up to 6 years for diet, islet autoantibodies, and T1D.
Several dietary factors have been suspected to play a role in the development of advanced islet autoimmunity (IA) and/or type 1 diabetes (T1D), but the evidence is fragmentary. A prospective population-based cohort of 6081 Finnish newborn infants with HLA-DQB1-conferred susceptibility to T1D was followed up to 15 years of age. Diabetes-associated autoantibodies and diet were assessed at 3- to 12-month intervals.
View Article and Find Full Text PDFFruit and vegetable intake has been associated with a reduced risk of many chronic diseases. These foods are the main dietary source of carotenoids. The aim of the present study was to evaluate the associations between dietary intake and serum concentrations of α- and β-carotene in a sample of young Finnish children from the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention (DIPP) Study.
View Article and Find Full Text PDFBreastfeeding, age at introduction of foods, and food diversity in infancy were studied for associations with advanced islet autoimmunity and type 1 diabetes. During 1996--2004, a total of 5,915 newborns with human leukocyte antigen-conferred susceptibility to type 1 diabetes were enrolled in the prospective Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study. Children were assessed at intervals of 3-12 months for the appearance of 4 types of islet autoantibodies and type 1 diabetes up to the age of 15 years.
View Article and Find Full Text PDFBackground: Early-life vitamin D intake has been linked to asthma risk in childhood, but the role of longitudinal vitamin D exposure has not been previously evaluated. We investigated the association between vitamin D intake during the first 4 years of life and asthma risk by age 5.
Methods: Within a Finnish population-based birth cohort, 182 incident asthma cases were matched to 728 controls on sex, genetic risk for type 1 diabetes, delivery hospital, and time of birth.
Article Synopsis
- The study aimed to explore how the composition of serum fatty acids in infants is linked to the risk of developing autoimmune indicators of type 1 diabetes, particularly focusing on the role of long-chain n-3 fatty acids in reducing this risk.
- Researchers conducted a detailed analysis comparing the serum fatty acid profiles of infants with islet autoimmunity to those without, using a cohort from the Finnish Type 1 Diabetes Prediction and Prevention Study.
- The findings revealed significant differences in fatty acid levels based on breastfeeding, with specific fatty acids being associated with both decreased and increased risks of autoimmunity, indicating that early diet may play a crucial role in immunological outcomes.
Article Synopsis
- * A study involving 4921 mothers tracked dietary intake of folate, folic acid, and vitamin D and assessed their children's CMA development using health registries.
- * Findings indicate that higher folate and folic acid supplement use may increase CMA risk, whereas dietary vitamin D intake during pregnancy could reduce this risk; educated mothers who take more supplements might be seeking better health outcomes for their children.
Background: The consumption of foods rich in n-3 polyunsaturated fatty acids has been proposed to protect against childhood asthma. This study explores the association of food consumption (including cow's milk (CM)-free diet) in early life and the risk of atopic and non-atopic asthma.
Methods: Food intake of 182 children with asthma and 728 matched controls was measured using 3-day food records, within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study cohort.
Importance: The role of microbial exposure during early life in the development of type 1 diabetes mellitus is unclear.
Objective: To investigate whether animal contact and other microbial exposures during infancy are associated with the development of preclinical and clinical type 1 diabetes.
Design, Setting, And Participants: A birth cohort of children with HLA antigen-DQB1-conferred susceptibility to type 1 diabetes was examined.