Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci.

Rationale: Mitral valve prolapse (MVP) is a common valvopathy that leads to mitral insufficiency, heart failure, and sudden death. Functional genomic studies in mitral valves are needed to better characterize MVP-associated variants and target genes.

Objective: To establish the chromatin accessibility profiles and assess functionality of variants and narrow down target genes at MVP loci.