Re-evaluating prognostic factors for cervical cancer with lymph node metastasis: a Japanese multicenter cohort study based on FIGO 2018.

Background: In 2018, the International Federation of Gynecology and Obstetrics (FIGO) revised its cervical cancer staging system to enhance clinical relevance, notably by categorizing lymph node metastases (LNM) as an independent stage IIIC. This multicenter study evaluates the prognostic implications of the FIGO 2018 classification within a Japanese cohort.

Methods: This study included 1468 patients with cervical cancer.

Prognostic significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in uterine carcinosarcoma.

Introduction: Uterine carcinosarcoma (UCS) and uterine sarcomas (US) are rare but aggressive cancer with poor prognoses. The prognostic value of systemic inflammatory response (SIR) indicators, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), in predicting outcomes of UCS and US remains unclear. This study investigated the prognostic significance of SIR indicators for UCS and US.

Colorectal anastomotic leakage after conversion surgery for advanced endometrial cancer treated with lenvatinib plus pembrolizumab: a case report.

The combination therapy of lenvatinib plus pembrolizumab (LP) is increasingly recognized as an important second-line regimen for advanced or recurrent endometrial cancer (EC). However, the safety and efficacy of conversion surgery with low anterior rectal resection for unresectable EC following LP therapy is unknown. A 37-year-old woman was referred with unresectable EC with pleural fluid, peritoneal dissemination, and ascites.

Changes in Physical Activity Across Cancer Diagnosis and Treatment Based on Smartphone Step Count Data Linked to a Japanese Claims Database: Retrospective Cohort Study.

Background: Although physical activity (PA) is recommended for patients with cancer, changes in PA across cancer diagnosis and treatment have not been objectively evaluated.

Objective: This study aimed to assess the impact of cancer diagnosis and treatment on PA levels.

Methods: This was a retrospective cohort study using a Japanese claims database provided by DeSC Healthcare Inc, in which daily step count data, derived from smartphone pedometers, are linked to the claims data.

Near-infrared fluorescent HaloTag ligands for efficient organelle labelling in live cells.

A series of HaloTag ligands that incorporate near-infrared (NIR)-emissive phospha-rhodamine (POR) dyes have been developed. The PORs that contain dealkylated amino groups exhibit a hypsochromic shift in their absorption and emission wavelengths. Subsequent refinement of the POR spirocyclization equilibrium significantly enhanced membrane permeability, thereby leading to a substantial reduction in the time necessary for labelling.

A stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response.

Fatty acids are known to have significant effects on the properties of cancer cells. Therefore, these compounds have been incorporated into therapeutic strategies. However, few studies have examined the effects of individual fatty acids and their interactions in depth.

Electronic patient-reported outcomes as digital therapeutics for patients with cancer: a narrative review of current practices and future directions.

Improved cancer treatment outcomes have increased the demand for medical care that considers the quality of life of patients with cancer. Patient-reported outcomes (PROs) help assess the quality of life because they involve direct evaluation of the patients. Recently, electronic PROs (ePROs) have been used in clinical cancer care settings in Europe and the United States.

ARCaDia: single-round screening of a DNA-type targeted covalent binder possessing a latent warhead.

A covalent binder for a target protein was obtained by a direct single-round screening of a latent-warhead-modified DNA library affinity/reactivity-based co-selection of aptameric deoxyribonucleic acid (ARCaDia), followed by a top -mer analysis. The optimal position of the conjugated warhead on the selected aptamer was simultaneously identified.

Assessing the energy load and environmental footprint of potash fertilizer production in Iran.

The goal of this research was to analyze the energy and environmental impact of KCL and K2SO4 production and provide recommendations for enhancing energy efficiency and environmental practices. Data was collected through face-to-face interviews at two potash plants and the CML methodology was employed to assess impact categories. Inventory data for production inputs were sourced from the Ecoinvent, BUWAL 250, and LCA Food DK databases within the Simapro 8.

Short-term Outcomes of Robot-assisted Colectomy Using the Overlap Method for Right-sided Colon Cancer.

Background/aim: The recent development of minimally invasive surgery has led to transition from laparoscopic right colectomy (LC) to robot-assisted right colectomy (RC) in Japan. However, it is unclear whether the introduction of RC in municipal hospitals could be as safe as that in high-volume centers in Japan. Therefore, this retrospective study aimed to compare the short-term operative outcomes of RC and LC for right colon cancer at a local municipal hospital in Japan.

Short-term Outcomes of Robotic Left Colectomy Reconstructed by Intracorporeal Overlap Anastomosis for Left-sided Colon Cancer: A Single-center Report from Japan.

Background/aim: Surgery for colon cancer requires covering a wide area and performing both tumor resection and precise lymph node dissection. Robotic left-sided colectomy (RLC) has not been thoroughly established due to the rarity of descending colon cancer. Therefore, we investigated 19 patients who underwent RLC for left-sided colon cancer.

Optimizing water use efficiency in greenhouse cucumber cultivation: A comparative study of intelligent irrigation systems.

This study investigated the use of an intelligent irrigation system for greenhouse cucumber cultivation, aiming to manage water consumption efficiently. During the initial phase, irrigation was tested at four levels: 80%, 90%, and 100% of Field Capacity (FC), and Conventional Flood Irrigation (CFI). Data on environmental conditions and water usage were meticulously recorded.

A case of grade1 follicular lymphoma diagnosed by laparoscopic lymph node resection: differentiating from late lymph node recurrence of endometrial cancer.

Follicular lymphoma is a common hematologic malignancy; however, it is less common among all malignant diseases and is difficult to suspect in advance due to the lack of specific clinical findings. Here, we report a case in which a late recurrence of corpus cancer was first suspected and finally diagnosed as follicular lymphoma. A 67-year-old female presented to our department with enlarged pelvic lymph nodes.

SMARCA4-deficient uterine tumors in young women: response to immune checkpoint inhibitors.

Unlabelled: SMARCA4-deficient tumors have been reported in various organs and are associated with a poor prognosis. SMARCA4-deficient undifferentiated uterine sarcoma (SDUS) was first described in 2018. Conversely, loss of SMARCA4 (BRG1) expression, as observed by immunostaining, has been observed in several cases of undifferentiated endometrial carcinoma.

Effects of website-based risk communication of radio-frequency electromagnetic fields on general public.

Background: Radio-frequency electromagnetic fields (RF-EMFs) are utilized in communications and appliances and are indispensable in daily life. However, some people have concerns about the adverse health effects of RF-EMFs; therefore, effective risk communication (RC) is needed in this field.

Objective: In this study, we investigate public attitudes towards RF-EMFs and examine the impact of RC via a website on these attitudes and objective knowledge.

Origin of Peritoneal Cancer With Features of High-grade Serous Carcinoma: A Detailed Molecular Analysis.

Primary peritoneal cancer has characteristics similar to high-grade serous carcinomas of ovarian and fallopian tube origin. However, the relationship between endometriosis and primary peritoneal cancer is not well understood. This study focuses on a case of peritoneal cancer in a patient who had undergone hysterectomy and bilateral salpingo-oophorectomy 5 yr before.

Multiple calcifying fibrous tumors from gastric and retroperitoneal tissue: A case report.

Introduction And Importance: Calcifying fibrous tumor (CFT) is a rare benign mesenchymal lesion that has been occurred in the gastrointestinal tract, especially occurs most commonly in the stomach and the small and large intestines.

Case Presentation: 74-year-old woman was admitted to our hospital with complaints of epigastric discomfort. Whole-body computed tomography (CT) revealed a 2.

Dicopper Complexes of -Cresol-2,6-bis(amide-tether-dpa) (X = MeO and Cl): Selective ROS Generation and Cytotoxicity Enhancement Controlled by Electronic and Hydrophobic Effects of the MeO and Cl Groups.

Two new -cresol-2,6-bis(amide-tether-dpa) ligands (HL, X = MeO and Cl) and their dicopper complexes [Cu(μ-1,1-OAc)(μ-1,3-OAc)(L)]Y (Y = PF , OAc ) and [Cu(μ-1,3-OAc)(L)]Y (Y = ClO , OAc ) were synthesized. The electronic and hydrophobic effects of the MeO and Cl groups were examined compared with nonsubstituted complex [Cu(μ-1,1-OAc)(μ-1,3-OAc)(L)] (). The electronic effects were found in crystal structures, spectroscopic characterization, and redox potentials of these complexes.

Investigation of the clinical implications of anterior cervical invasion in locally advanced cervical squamous cell carcinoma.

Purposes: This study investigates the clinical significance of the anterior parametrical invasion in surgically treated patients with cervical squamous cell carcinoma (SCC).

Methods: We included patients diagnosed with cervical SCC with local lesions classified as T2b, who were treated at our department between January 2006 and December 2020. We evaluated the degree of anterior invasion using pretreatment magnetic resonance imaging and divided patients into three groups: partial, equivocal, and full invasion.