Transplantation of retinoic acid treated murine embryonic stem cells & behavioural deficit in Parkinsonian rats.

Background & Objectives: Stem cell therapy has been considered as an ideal option for the treatment of Parkinson's disease. Murine embryonic stem cells (mESCs)-derived dopaminergic (DA) neurons may substitute the degenerated neurons in the brain. In this study we generated highly enriched cultures of neural progenitors from mESCs and grafted them into the striatum of Parkinsonian rats to evaluate their ability to improve impaired function.

Formation of embryoid bodies from mouse embryonic stem cells cultured on silicon-coated surfaces.

Embryoid bodies (EBs) are primitive embryonic structures derived from differentiating embryonic stem cells (ESCs). Many techniques have been used to obtain EBs. Improving the technique of EB formation can help in achieving better results in ESCs differentiation into neurons, myocardiocytes, haemopoeitic cells, and others.

Morphometric evaluation of the neuroprotective effect of deprenyl on postaxotomic motor neuron losses.

Newborn rats were used to evaluate the neuroprotective effect of deprenyl on spinal motor neurons. The left sides were axotomized at age day 5 and the right sides were kept as a control. One hour after surgery, the operated animals received a daily dose of deprenyl intraperitoneally for 21 days.