Exploiting mechanisms for hierarchical branching structure of lung airway.

The lung airways exhibit distinct features with long, wide proximal branches and short, thin distal branches, crucial for optimal respiratory function. In this study, we investigated the mechanism behind this hierarchical structure through experiments and modeling, focusing on the regulation of branch length and width during the pseudoglandular stage. To evaluate the response of mouse lung epithelium to fibroblast growth factor 10 (FGF10), we monitored the activity of extracellular signal-regulated kinase (ERK).

Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease.

In human celiac disease (CeD) HLA-DQ2.5 presents gluten peptides to antigen-specific CD4 T cells, thereby instigating immune activation and enteropathy. Targeting HLA-DQ2.

10-GHz-clock time-multiplexed non-degenerate optical parametric oscillator network with a variable planar lightwave circuit interferometer.

A coherent XY machine (CXYM) is a physical spin simulator that can simulate the XY model by mapping XY spins onto the continuous phases of non-degenerate optical parametric oscillators (NOPOs). Here, we demonstrated a large-scale CXYM with >47,000 spins by generating 10-GHz-clock time-multiplexed NOPO pulses via four-wave mixing in a highly nonlinear fiber inside a fiber ring cavity. By implementing a unidirectional coupling from the ith pulse to the (i + 1)th pulse with a variable 1-pulse delay planar lightwave circuit interferometer, we successfully controlled the effective temperature of a one-dimensional XY spin network within two orders of magnitude.

Collective and synchronous dynamics of photonic spiking neurons.

Nonlinear dynamics of spiking neural networks have recently attracted much interest as an approach to understand possible information processing in the brain and apply it to artificial intelligence. Since information can be processed by collective spiking dynamics of neurons, the fine control of spiking dynamics is desirable for neuromorphic devices. Here we show that photonic spiking neurons implemented with paired nonlinear optical oscillators can be controlled to generate two modes of bio-realistic spiking dynamics by changing optical-pump amplitude.

A cell based assay for evaluating binding and uptake of an antibody using hepatic nonparenchymal cells.

Evaluation of the binding and uptake of an antibody in liver non-parenchymal cells (NPC), including liver sinusoidal endothelial cells, is important for revealing its pharmacokinetic (PK) behavior, since NPC has important roles in eliminating an antibody from the blood via the Fc fragment of IgG receptor IIB (FcγRIIB). However, there is currently no in vitro quantitative assay using NPC. This study reports on the development of a cell-based assay for evaluating the binding and uptake of such an antibody using liver NPC of mice and monkeys.

Prediction of Human Pharmacokinetics Profile of Monoclonal Antibody Using hFcRn Transgenic Mouse Model.

Human pharmacokinetics (PK) profiles of monoclonal antibodies (mAbs) are usually predicted using non-human primates (NHP), but this comes with drawbacks in terms of cost and throughput. Therefore, we established a human PK profile prediction method using human neonatal Fc receptor (hFcRn) transgenic mice (TgM). We administered launched 13 mAbs to hFcRn TgM and measured the concentration in plasma using electro-chemiluminescence immunoassay.

A simple low-latency real-time certifiable quantum random number generator.

Quantum random numbers distinguish themselves from others by their intrinsic unpredictability arising from the principles of quantum mechanics. As such they are extremely useful in many scientific and real-world applications with considerable efforts going into their realizations. Most demonstrations focus on high asymptotic generation rates.

Continuous and long-term stabilization of degenerate optical parametric oscillators for large-scale optical hybrid computers.

The minimum requirements for an optical reservoir computer, a recent paradigm for computation using simple algorithms, are nonlinearity and internal interactions. A promising optical system satisfying these requirements is a platform based on coupled degenerate optical parametric oscillators (DOPOs) in a fiber ring cavity. We can expect advantages using DOPOs for reservoir computing with respect to scalability and reduction of excess noise; however, the continuous stabilization required for reservoir computing has not yet been demonstrated.

Observation of binary phase states of time-multiplexed degenerate optical parametric oscillator pulses generated using a nonlinear fiber Sagnac loop.

We generated time-multiplexed degenerate optical parametric oscillator (DOPO) pulses using a nonlinear fiber Sagnac loop as a phase-sensitive amplifier (PSA), where the pump and amplified light in pump-signal-idler degenerate four-wave mixing can be spatially separated. By placing the PSA in a fiber cavity, we successfully generated more than 5000 time-multiplexed DOPO pulses. We confirmed the bifurcation of pulse phases to 0 or relative to the pump phase, which makes them useful for representing Ising spins in an Ising model solver based on coherent optical oscillator networks.

Experimental investigation of performance differences between coherent Ising machines and a quantum annealer.

Physical annealing systems provide heuristic approaches to solving combinatorial optimization problems. Here, we benchmark two types of annealing machines-a quantum annealer built by D-Wave Systems and measurement-feedback coherent Ising machines (CIMs) based on optical parametric oscillators-on two problem classes, the Sherrington-Kirkpatrick (SK) model and MAX-CUT. The D-Wave quantum annealer outperforms the CIMs on MAX-CUT on cubic graphs.

Understanding dynamics of coherent Ising machines through simulation of large-scale 2D Ising models.

Many problems in mathematics, statistical mechanics, and computer science are computationally hard but can often be mapped onto a ground-state-search problem of the Ising model and approximately solved by artificial spin-networks of coupled degenerate optical parametric oscillators (DOPOs) in coherent Ising machines. To better understand their working principle and optimize their performance, we analyze the dynamics during the ground state search of 2D Ising models with up to 1936 mutually coupled DOPOs. For regular as well as frustrated and disordered 2D lattices, the machine finds the correct solution within just a few milliseconds.

Prevalence and Characteristic Features of Deep Venous Thrombosis in Patients with Severe Motor and Intellectual Disabilities.

Sudden death associated with patients with severe motor and intellectual disabilities (SMID) have been thought to be caused in part by venous thromboembolism (VTE), but actual situation of VTE in SMID is not clear. We examined the prevalence and location of deep venous thrombosis (DVT), and the relation of the development of crural veins in 16 patients with SMID, using ultrasonography. The maximum diameter of soleal vein was 1.

Nucleosome Positioning and Gene Regulation of the Gene in the Renal Proximal Tubular Epithelial Cells.

Filtered glucose is mostly reabsorbed by sodium-glucose cotransporter 2 (SGLT2) in the proximal tubules. SGLT2 is predominantly expressed in the human kidney. However, the regulatory mechanisms for gene expression in the human kidney remain unclear.

Wideband slow short-pulse propagation in one-thousand slantingly coupled L3 photonic crystal nanocavities.

Coupled cavities have been used previously to realize on-chip low-dispersion slow-light waveguides, but the bandwidth was usually narrower than 10 nm and the total length was much shorter than 1 mm. Here we report long (0.05-2.

Four-dimensional entanglement distribution over 100 km.

High-dimensional quantum entanglement can enrich the functionality of quantum information processing. For example, it can enhance the channel capacity for linear optic superdense coding and decrease the error rate threshold of quantum key distribution. Long-distance distribution of a high-dimensional entanglement is essential for such advanced quantum communications over a communications network.

Human pursuance of equality hinges on mental processes of projecting oneself into the perspectives of others and into future situations.

In the pursuance of equality, behavioural scientists disagree about distinct motivators, that is, consideration of others and prospective calculation for oneself. However, accumulating data suggest that these motivators may share a common process in the brain whereby perspectives and events that did not arise in the immediate environment are conceived. To examine this, we devised a game imitating a real decision-making situation regarding redistribution among income classes in a welfare state.

Partner selection and emergence of the merit-based equity norm.

The merit-based equity norm is a widely observed principle of fairness in resource distribution, in which the resources acquired by each individual are expected to be proportional to the contribution. Despite the empirical significance of this principle, theoretical progress in evolutionary explanations of the fairness norm has been limited to an egalitarian norm. In this study, we examined the effect of partner selection on the evolution of the merit-based equity norm in a simple bargaining game.

A fully programmable 100-spin coherent Ising machine with all-to-all connections.

Unconventional, special-purpose machines may aid in accelerating the solution of some of the hardest problems in computing, such as large-scale combinatorial optimizations, by exploiting different operating mechanisms than those of standard digital computers. We present a scalable optical processor with electronic feedback that can be realized at large scale with room-temperature technology. Our prototype machine is able to find exact solutions of, or sample good approximate solutions to, a variety of hard instances of Ising problems with up to 100 spins and 10,000 spin-spin connections.

A coherent Ising machine for 2000-node optimization problems.

The analysis and optimization of complex systems can be reduced to mathematical problems collectively known as combinatorial optimization. Many such problems can be mapped onto ground-state search problems of the Ising model, and various artificial spin systems are now emerging as promising approaches. However, physical Ising machines have suffered from limited numbers of spin-spin couplings because of implementations based on localized spins, resulting in severe scalability problems.

10 GHz clock time-multiplexed degenerate optical parametric oscillators for a photonic Ising spin network.

A coherent Ising machine based on degenerate optical parametric oscillators (DOPOs) is drawing attention as a way to find a solution to the ground-state search problem of the Ising model. Here we report the generation of time-multiplexed DOPOs at a 10 GHz clock frequency. We successfully generated >50,000 DOPOs using dual-pump four-wave mixing in a highly nonlinear fiber that formed a 1 km cavity, and observed phase bifurcation of the DOPOs, which suggests that the DOPOs can be used as stable artificial spins.

Epigenetic regulation of drug transporter expression in human tissues.

Drug transporters are expressed in a number of tissues such as the intestine, liver, and kidney, and play key roles in drug absorption, distribution, and excretion. Variations in drug transporter gene expression significantly contribute to interindividual differences in drug responses. Epigenetic regulation of drug transporter genes has recently emerged as an important mechanism.

Deep Vein Thrombosis in Patients with Severe Motor and Intellectual Disabilities, Especially Diagnosis and Prevention of Recurrence for Chronic Thrombosis-Serial Changes of Sonography and D-Dimer.

Most patients with severe motor and intellectual disabilities (SMID) have restricted mobility capability and have been bedridden for long periods because of paralysis of the extremities caused by abnormal muscular tonicity due to cerebral palsy and developmental disabilities. Such patients are associated with a high risk of complications like deep vein thrombosis (DVT). Here, we report twelve patients (42.

Ultimate low system dark-count rate for superconducting nanowire single-photon detector.

The dark-count rate (DCR) is a key parameter of single-photon detectors. By introducing a bulk optical band-pass filter mounted on a fiber-to-fiber optical bench cooled at 3 K and blocking down to 5 μm, we suppressed the DCR of a superconducting nanowire single-photon detector by more than three orders of magnitude. The DCR is limited by the blackbody radiation through a signal passband of 20-nm bandwidth.

On-chip generation and demultiplexing of quantum correlated photons using a silicon-silica monolithic photonic integration platform.

We demonstrate the generation and demultiplexing of quantum correlated photons on a monolithic photonic chip composed of silicon and silica-based waveguides. Photon pairs generated in a nonlinear silicon waveguide are successfully separated into two optical channels of an arrayed-waveguide grating fabricated on a silica-based waveguide platform.