This study aimed to evaluate the ability of serial whole-body dynamic PET/CT to differentiate physiological from abnormal F-FDG uptake in the abdomen and pelvis of gynecological cancer patients. We conducted a retrospective study of 61 F-FDG PET/CT examinations for suspected gynecological malignancies or metastases between March 2018 and January 2020. Our protocol included four-phase dynamic whole-body scans.
View Article and Find Full Text PDFObjectives: The present study investigated various image reconstruction protocols for amyloid PET using phantom test criteria published by the Japanese Society of Nuclear Medicine (JSNM) and compared them with the composite standardized uptake value ratio (cSUVR) in clinical imaging.
Methods: Hoffman 3D phantoms and cylindrical phantoms were collected for 30 min according to the JSNM guidelines. Images were created under various reconstruction protocols by three physical evaluation items in the guidelines and were assessed: gray matter/white matter contrast (%contrast), uniformity (SDuROImean), and image noise [coefficient of variation (CV)].
Respiration gating is used in PET to prevent image quality degradation due to respiratory effects. In this study, we evaluated a type of data-driven respiration gating for continuous bed motion, OncoFreeze AI, which was implemented to improve image quality and the accuracy of semiquantitative uptake values affected by respiratory motion. F-FDG PET/CT was performed on 32 patients with lung lesions.
View Article and Find Full Text PDFVariable-speed continuous bed motion F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG-PET/CT), a reliable imaging technique, allows setting the bed motion speed for arbitrary sections of the body. The purpose of this study was to evaluate the relationship between the PET image quality and the bed speed following shortening of the scanning time for the lower extremities to achieve whole-body acquisition optimization of the examination time. Four sets of images were created by editing four-phase dynamic whole-body PET/CT images acquired at a bed speed of 6 and 14 mm/s in the trunk and lower extremities, respectively.
View Article and Find Full Text PDFObjectives: Serial changes of focal uptake in whole-body dynamic positron emission tomography (PET) imaging were assessed and compared with those in early-delayed imaging to differentiate pathological uptake from physiological uptake in the colorectal area, based on the change in uptake shape.
Methods: In 60 patients with at least 1 pathologically diagnosed colorectal cancer or adenoma, a serial 3 min dynamic whole-body PET/computed tomography imaging was performed four times around 60 min after the administration of F-fluorodeoxyglucose (FDG) to create a conventional (early) image by summation. Delayed imaging was performed separately at 110 min after FDG administration.
Hydrogen sulfide (HS) is a well-known inhibitor of the mitochondrial electron transport chain (ETC). HS also increases intracellular Ca levels in astrocytes, which are glial cells and that supply lactate as an energy substrate to neurons. Here, we examined the relationship between HS-induced metabolic changes and Ca responses in spinal cord astrocytes.
View Article and Find Full Text PDFHydrogen sulfide (HS) has a variety of physiological functions. HS reportedly increases intracellular Ca concentration ([Ca]) in astrocytes. However, the precise mechanism and functional role of this increase are not known.
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