Publications by authors named "Takeshi Morinaga"

Article Synopsis
  • Interval appendectomy is often advised for patients with abscesses caused by perforated appendicitis, but rare complications like tuberculous peritonitis have not been widely reported.
  • A 67-year-old male with a history of laryngeal cancer initially improved after conservative treatment for appendicitis-associated ileal abscess but later returned with symptoms of peritonitis, leading to surgery that revealed tuberculous peritonitis.
  • The patient was successfully treated with antituberculosis medication and discharged after 8 days, highlighting the importance of monitoring for rare but serious complications in immunocompromised patients following appendicitis treatment.
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Purpose: The concept of oligometastasis, which represents limited metastatic disease, has recently gained interest, accompanied by a more detailed classification. This study aims to investigate the relationship between the treatment course and prognosis in patients with a recurrence of esophageal squamous cell carcinoma (ESCC) after curative esophagectomy.

Methods: 126 patients with ESCC recurrence after curative resection were enrolled in this study.

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Article Synopsis
  • A 49-year-old woman with a long history of VP shunt revisions developed generalized peritonitis due to a shunt catheter migrating into her small intestine after 30 years.
  • Laparoscopic surgery was performed for the peritonitis, revealing a perforation in the intestine caused by the shunt catheter, which was successfully removed.
  • The patient subsequently had her VP shunt reconstructed and was discharged 45 days later without any complications.
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Cases of adult liver transplant recipients with a postoperative right-side acquired diaphragmatic hernia are extremely rare. In this report, we describe an adult case of right-side acquired diaphragmatic hernia 15 years after living donor liver transplant. A 27-year-old woman was diagnosed with pancreatic insulinoma with multiple metastases in the liver.

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Article Synopsis
  • Two cases are reported where a colonoscope became trapped in an inguinal hernia during a medical procedure.
  • In both instances, the colonoscope was successfully removed using manual reduction guided by fluoroscopy, allowing for the completion of the colonoscopy.
  • One patient had advanced sigmoid cancer diagnosed and treated with surgery, while both hernias were resolved following the respective interventions.
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Background: Some reports showed the immune tolerance of soluble human leukocyte antigen E (HLA-E), but the role that soluble HLA-E plays in gastric cancer (GC) is unknown. We aimed to clarify the molecular mechanism and clinical significance of soluble HLA-E in GC.

Methods: We examined the expression of HLA-E on GC cells and soluble HLA-E under co-culture with natural killer (NK) cells in a time-dependent manner.

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Background: The NKG2A/HLA-E pathway functions as an immune checkpoint with potential for inhibition using therapeutic antibodies. Through this pathway, immune cells lose activity, which allows cancers to progress. We aimed to determine whether HLA-E expression combined with NK cell status serves as a prognostic biomarker for gastric cancer (GC).

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Background: This study aimed to examine whether preoperative serum transferrin, a rapid-turnover protein, correlates with short- and long-term outcomes after esophagectomy.

Methods: Preoperative transferrin levels, calculated by summing serum iron and unsaturated iron-binding capacity, were evaluated in 224 patients who underwent esophagectomy for stage I-III esophageal cancer without preoperative treatment. Transferrin levels are directly proportional to total iron-binding capacity (TIBC), and we defined TIBC < 250 μg/dL as low transferrin.

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A 41-year-old woman was admitted to our hospital for epigastralgia. She had been admitted to another hospital for fundic gland polyposis (FGP) without any symptoms, and no malignancy had been noted in her previous endoscopy. However, a biopsy performed at our hospital revealed adenocarcinoma, and computed tomography (CT) revealed multiple liver and peritoneal metastases.

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Purpose: High preoperative hemoglobin A1c (HbA1c) levels have been suggested to increase complications after esophagectomy. Minimally invasive esophagectomy (MIE) is less invasive than open esophagectomy (OE) and may reduce postoperative complications. However, it has not been established whether MIE contributes to low morbidity in patients with high preoperative HbA1c levels.

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Stage IV Gastric/Esophagogastric junction cancer (G/EGJ) has an unfavorable prognosis and poor curability. In this study, we report the case of long-term survival after multidisciplinary treatments for advanced esophagogastric junction cancer. A 53-year-old male patient was diagnosed with HER2 positive advanced esophagogastric junction cancer and mediastinal and paraaortic lymph node metastasis.

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Aim: Many studies have shown that patients with mental disorders are less likely than non-psychiatric patients to be diagnosed with or treated for various types of cancers because of their low awareness and understanding of the disease as well as reduced ability to cooperate with medical staff. We analyzed the clinical features of patients with colorectal cancer (CRC) and preexisting mental illness.

Methods: All patients underwent primary tumor resection for CRC.

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Family 1: a 39-year-old woman and her sister were admitted to our hospital for fundic gland polyps (FGPs). Their mother died of gastric cancer with FGPs. We performed repeated biopsies at close intervals, suspecting gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS).

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Purpose: In recent years, the concept of oligometastasis, which represents limited metastatic disease, has gained much interest. This study focuses on the oligometastatic recurrence (OLR) of esophageal squamous cell carcinoma (ESCC) after esophagectomy.

Methods: From among 514 patients who underwent curative resection for ESCC at our hospital between April 2005 and December 2019, 97 patients with recurrence were enrolled in this study.

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Background: The predictive significance of programmed death ligand 1 (PD-L1) for programmed death 1 (PD-1) inhibitors remains unclear in gastric cancer (GC) due to the dynamic alteration by treatments. We aimed to elucidate the effects of trastuzumab (Tmab) on PD-L1 expression in GC.

Methods: PD-L1 expression was evaluated by multicolour flow cytometry analysis after co-culturing GG cell lines and immune cells with Tmab.

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Wall turbulence has a sublayer where one-point statistics, e.g., the mean velocity and the variances of some velocity fluctuations, vary logarithmically with the distance from the wall.

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Article Synopsis
  • A study was conducted on 504 male patients who underwent esophagectomy for cancer to examine how the type of person providing support affects patient outcomes, focusing on the role of a wife as a key support figure.* -
  • Results showed that male patients with their wives as key support had significantly better overall survival rates compared to those without their wives, indicating their presence is a protective factor for recovery.* -
  • However, having a wife did not influence nutritional status or survival after cancer recurrence, suggesting that while their support improves survival, it may not directly impact other postoperative health aspects.*
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Background: Hepatic artery anomalies are often observed, and the variations are wide-ranging. We herein report a case of pancreatic cancer involving the common hepatic artery (CHA) that was successfully treated with pancreaticoduodenectomy (PD) without arterial reconstruction, thanks to anastomosis between the root of CHA and proper hepatic artery (PHA), which is a very rare anastomotic site.

Case Presentation: A 78-year-old woman was referred to our department for the examination of a tumor in the pancreatic head.

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Within wall turbulence, there is a sublayer where the mean velocity and the variance of velocity fluctuations vary logarithmically with the height from the wall. This logarithmic scaling is also known for the mean concentration of a passive scalar. By using heat as such a scalar in a laboratory experiment of a turbulent boundary layer, the existence of the logarithmic scaling is shown here for the variance of fluctuations of the scalar concentration.

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Multicystic biliary hamartoma (MCBH) is a rare cystic disease of the liver. We herein report a case of MCBH associated with extremely elevated levels of serum carbohydrate antigen (CA) 19-9. A 53-year-old man was referred to our hospital because of extremely elevated CA19-9 levels (more than 12,000 U/mL).

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BAY 81-8973, a new full length recombinant FVIII product, has been developed for prophylaxis and on-demand therapy in patients with hemophilia A. LEOPOLD II was a phase 2/3 study comparing prophylaxis versus on-demand treatment with BAY 81-8973. The analysis herein evaluated the clinical profile in Japanese subjects enrolled in LEOPOLD II.

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Ataxia-telangiectasia mutated (ATM) is a serine/threonine protein kinase that plays a central role in DNA damage response (DDR). A recent study reported that oxidized ATM can be active in the absence of DDR. However, the issue of where ATM is activated by oxidative stress remains unclear.

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