The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.

The herpes simplex virus (HSV) type I alkaline nuclease, UL12, has 5'-to-3' exonuclease activity and shares homology with nucleases from other members of the family. We previously reported that a UL12-null virus exhibits a severe defect in viral growth. To determine whether the growth defect was a result of loss of nuclease activity or another function of UL12, we introduced an exonuclease-inactivating mutation into the viral genome.

Comparative effect of sesamin and episesamin on the activity and gene expression of enzymes in fatty acid oxidation and synthesis in rat liver.

Sesamin is one of the most abundant lignans in sesame seed. Episesamin, a geometrical isomer of sesamin, is not a naturally occurring compound and is formed during the refining process of non-roasted sesame seed oil. We compared the physiological activities of these compounds in affecting hepatic fatty acid metabolism in rat liver.