Publications by authors named "Takeshi Fujiwara"

Background: Hypertension is a key risk factor for death and disability, and blood pressure reduction is associated with significant reductions in cardiovascular risk. Large trials have shown that interventions including self-monitoring of blood pressure can reduce blood pressure but real-world data from wider implementation are lacking.

Aim: The self-monitoring and management service evaluation in primary care (SHIP) study will evaluate a novel digital intervention for hypertension management and medication titration platform ("Hypertension-Plus") that is currently undergoing initial implementation into primary care in several parts of the UK.

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Background: Nocturnal home blood pressure monitoring (HBPM) may identify people at higher cardiovascular disease (CVD) risk than expected.

Objectives: The aim of this study was to examine the association between office-masked nocturnal hypertension, defined by HBPM, and CVD risk in a clinical practice-based population.

Methods: Prospective observational study including Japanese high cardiovascular-risk participants.

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Article Synopsis
  • * The WISDOM-Night Study aims to evaluate how wrist-based nighttime blood pressure (BP) monitoring impacts cardiovascular health by measuring BP at specific times while minimizing sleep disturbance, involving 2751 patients over a 7-year period.
  • * Additionally, some participants from this study will undergo echocardiography to explore the relationship between wrist-measured BP and heart structure, potentially providing valuable insights into nighttime BP's role in cardiovascular diseases.
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  • The Coupling study investigated how vascular biomarkers and supine blood pressure (BP) impact the risk of major cardiovascular events in outpatients over 30 with cardiovascular risk factors, involving 4716 participants during a median follow-up of 5 years.* -
  • Key findings revealed that higher cardio-ankle vascular index (CAVI) and lower ankle-brachial index (ABI) are associated with increased cardiovascular event risk, particularly when CAVI is ≥8.0 and ABI is ≤1.10.* -
  • The study emphasizes that uncontrolled supine hypertension (≥140/90 mmHg) is a significant risk factor, suggesting a need for better management of BP and vascular health in clinical practice, given that traditional
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  • Haptic Augmented Reality (HAR) is a technology that makes you feel different textures and qualities of physical objects by adding extra touch sensations.
  • The researchers created a special soft gadget that gives you a feeling of stickiness even after you lift your finger off the object.
  • They did two experiments showing that this new gadget can really make things feel stickier and that timing plays a big role in how real it feels, which could help in cool new tech like Virtual Reality and Mixed Reality!
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This study tested the hypothesis that differences in ethnicity impact the level of agreement between ambulatory blood pressure (ABP) and home BP (HBP) levels. A retrospective analysis of cross-sectional data from the UK and Japan was performed. Participants underwent office BP, daytime ABP, and HBP measurements.

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  • Hypertension in children and adolescents raises the risk of future hypertension and cardiovascular disease in adulthood, making prevention a key public health goal globally.
  • A review from Hypertension Research highlights key findings from 2023/24, including a higher prevalence of hypertension among female junior high students in Japan compared to males, and various hematological factors positively linked to blood pressure levels in young individuals.
  • The study emphasizes the need for regular hypertension screenings, early interventions, and education on dietary salt intake to lower hypertension risks and CVD burdens later in life.
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This study extended the theory of planned behaviour (TPB) and applied it to analyse influencing factors of food waste separation intention (FSI) among households in central Vietnam. Partial least squares structural equation modelling (PLS-SEM) was employed to analyse the data. The heterogeneity of factors contributing to FSI in cities of three levels was examined using multi-group analysis (MGA).

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  • * A 76-year-old man with obstructive jaundice underwent ERCP, but difficulties arose during insertion, leading to mild oral bleeding and the discovery of a tumor in the pyriform sinus via EGD.
  • * The case highlights the need for caution and thorough evaluation when faced with unexpected resistance during endoscopic procedures, particularly for less experienced endoscopists.
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  • * Single-balloon endoscopy was performed to manage biliary drainage, revealing a scar-like feature around the anastomosis and a milky whitish area indicating inflammation and fibrosis.
  • * Endoscopic dilatation through a pinhole in the stricture was successfully performed, and a plastic stent was placed, demonstrating a positive outcome and highlighting the utility of targeting the MWA as a landmark in guiding endoscopic interventions for challenging HJAS cases.
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  • Blood pressure thresholds for diagnosing hypertension differ across office, home, and ambulatory readings, which prompted an analysis using data from the HI-JAMP study involving 2322 patients.
  • Using Deming regression, the study identified corresponding BP thresholds; for instance, daytime ambulatory systolic BP closely matched home BP figures, indicating a strong correlation between the two methods.
  • The analysis confirmed that the home and ambulatory BP thresholds align with existing guidelines, making the findings clinically significant for hypertension management.
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For adopting recently introduced hypertension phenotypes categorized using office and out of office blood pressure (BP) for the diagnosis of hypertension and antihypertension drug therapy, it is mandatory to define the corresponding out of office BP with the specific target BP recommended by the major guidelines. Such conditions include white-coat hypertension (WCH), masked hypertension (MH), white-coat uncontrolled hypertension (WUCH), and masked uncontrolled hypertension (MUCH). Here, the authors review the relevant literature and discuss the related issue to facilitate the use of corresponding BPs for proper diagnosis of WCH, MH, WUCH, and MUCH in the setting of standard target BP as well as intensive target BP.

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Background: Home blood pressure (BP) is an important component of digital strategies for hypertension management. However, no studies have used the same device to investigate 24-hour BP control status in relation to different home BP control thresholds.

Methods: Participants in the general practitioner-based, multicenter HI-JAMP study (Home-Activity Information and Communication Technology-Based Japan Ambulatory Blood Pressure Monitoring Prospective) underwent office BP measurement, then 24-hour ambulatory BP monitoring, then home BP monitoring for 5 days.

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Recent innovations in digital technology have enabled the simultaneous accumulation, and the linking and analysis of time-series big data relating to several factors that influence blood pressure (BP), including biological indicators, physical activity, and environmental information. Various approaches can be used to monitor BP: in the office/clinic; at home; 24-h ambulatory recording; or with wearable and cuffless devices. Of these, home BP monitoring is a reliable and convenient method, and is recommended for hypertension management by current national and international guidelines.

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While home blood pressure (BP) measurement is recommended for hypertension management, the clinical implications of peak home BP values have not been well studied. This study investigated the association between pathological threshold or frequency of peak home BP and cardiovascular events in patients with ≥1 cardiovascular risk factor. The Japan Morning Surge-Home Blood Pressure (J-HOP) study enrolled participants from 2005-2012 with extended follow-up from December 2017 to May 2018, which generated the dataset for this analysis.

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A 70-year-old Japanese man with a submucosal gastric mass that continued to increase in size underwent endoscopic submucosal dissection using the pocket creation method. Histologically, some epithelial cell nuclei were enlarged, but there was little atypia overall and no sign of malignancy, suggesting a diagnosis of submucosal heterotopic gastric gland (SHGG). SHGG that enlarges over time has been associated with gastric cancer, but a preoperative diagnosis is difficult.

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Hypertension is the most frequent modifiable risk factor associated with cardiovascular disease (CVD) morbidity and mortality. Even in older people, strict blood pressure (BP) control has been recommended to reduce CVD event risks. However, caution should be exercised since older hypertensive patients have increased physical vulnerability due to frailty and multimorbidity, and older patients eligible for clinical trials may not represent the general population.

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