Publications by authors named "Takeomi Kikuchi"
Article Synopsis
- The study investigates the relationship between cell membrane dynamics and cell migration using Dictyostelium cells, focusing on whether changes in cell surface area are involved.
- Flattened cells displayed no membrane projections or folds and showed no changes in surface area during movement, indicating that cell surface area remains constant while migrating.
- The research reveals that a high turnover rate of the cell membrane plays a crucial role in cell migration, with membrane circulation occurring in a fountain-like motion that enhances migration speed.
Actin and myosin II play major roles in cell migration. Whereas pseudopod extension by actin polymerization has been intensively researched, less attention has been paid to how the rest of the actin cytoskeleton such as the actin cortex contributes to cell migration. In this study, cortical actin and myosin II filaments were simultaneously observed in migrating Dictyostelium cells under total internal reflection fluorescence microscopy.
View Article and Find Full Text PDF