Publications by authors named "Takele A Tefera"
Article Synopsis
- Infectious diseases like PPR, CCPP, SGPX, and pasteurellosis significantly affect sheep and goat farming in Ethiopia, prompting the need for effective vaccination strategies.
- The study aimed to evaluate the safety and immune response of goats receiving multiple vaccines at the same time, comparing them to those receiving single vaccines.
- Results showed that while multiple vaccines were effective against PPR, CCPP, and pasteurellosis, they did not generate a protective response against SGPX, and no adverse effects were noted.
Article Synopsis
- A bacterial pathogen causes serious infections, especially hemorrhagic septicemia in cattle and buffaloes, leading to high mortality and significant socio-economic challenges for smallholder farmers in Africa and Asia.
- Researchers have identified a novel vaccine target, PmSLP-3, which has shown strong protective effects in cattle against serogroup B strains.
- PmSLP-3, combined with Montanide ISA 61, effectively produces long-lasting immunity in cattle, demonstrating protection against both serogroup B and E challenges, with sustained antibody levels found for up to three years after vaccination.
Intranasally Delivered Adenoviral Vector Protects Chickens against Newcastle Disease Virus: Vaccine Manufacturing and Stability Assessments for Liquid and Lyophilized Formulations.
Omar Farnós Barbara Cristina Martins Fernandes Paes Belayneh Getachew Samia Rourou Ameni Chaabene Takele A Tefera
Vaccines (Basel)
December 2023
Newcastle disease (ND) remains a critical disease affecting poultry in sub-Saharan Africa. In some countries, repeated outbreaks have a major impact on local economies and food security. Recently, we developed an adenovirus-vectored vaccine encoding the Fusion protein from an Ethiopian isolate of Newcastle disease virus (NDV).
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- - This study aimed to identify and analyze the bacteria causing pneumonic pasteurellosis in Bonga sheep from Southwest Ethiopia, focusing on their antibiotic resistance and impact on sheep productivity.
- - Researchers used cultured nasal swabs from sheep at veterinary clinics, applying microbiological tests and species-specific PCR methods to confirm the presence of the bacteria and assess their antibiotic susceptibility.
- - The results showed that the isolation rate of pathogens was around 31.76%, with notable resistance to common antibiotics like chloramphenicol and penicillin G, confirming specific bacterial species as the causative agents of the disease.
Pasteurella multocida can infect a multitude of wild and domesticated animals, with infections in cattle resulting in hemorrhagic septicemia (HS) or contributing to bovine respiratory disease (BRD) complex. Current cattle vaccines against P. multocida consist of inactivated bacteria, which only offer limited and serogroup specific protection.
View Article and Find Full Text PDF[This corrects the article DOI: 10.1155/2020/4236807.].
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- Enzyme linked immunosorbent assays (ELISAs) have been designed to detect antibodies for contagious caprine pleuropneumonia (CCPP), with existing commercial kits being too expensive for many African labs.
- A new, cost-effective blocking ELISA (b-ELISA) was developed to identify antibodies against CCPP, utilizing a monoclonal antibody's epitope and positive serum samples for testing.
- The b-ELISA demonstrated high sensitivity (93%) and specificity (88%) and showed strong agreement with the commercial ELISA, indicating its effectiveness for diagnosing CCPP and monitoring during vaccination campaigns.