Publications by authors named "Takehito Imamura"
Article Synopsis
- * Biopsies from various tissues were analyzed for HSP70 and macrophage presence in women with different forms of endometriosis, showing higher HSP70 levels during menstruation and in women with endometriosis compared to controls.
- * GnRHa treatment significantly reduced HSP70 expression in cyst walls and related lesions, highlighting a potential impact of this treatment on endometriosis-related inflammation and pathology.
Background: We investigated the role of human heat-shock protein 70 (Hsp70) in Toll-like receptor 4 (TLR4)-mediated growth of endometriosis.
Methods: TLR4 expression was examined in macrophages (M) isolated in primary culture from the peritoneal fluid of women with and without endometriosis. The production of a number of macromolecules by non-treated M, Hsp70-treated M and after treatment with anti-TLR4 antibody was examined by enzyme linked immunosorbent assay (ELISA).