Publications by authors named "Takehiro Horikawa"
Article Synopsis
- Hypertensive emergencies can lead to serious organ damage, and this study aimed to investigate the role of the renin-angiotensin-aldosterone system (RAS) in such cases.
- The study included 63 patients with severe hypertension and various organ injuries, assessing their blood pressure and aldosterone levels.
- Results showed that higher aldosterone levels were linked to more organ damage and complications, suggesting that RAS plays a significant role in affecting patient outcomes during hypertensive emergencies.
Background: Hypertensive emergency is a critical disease that causes multifaceted sequelae, including end-stage kidney disease and cardiovascular disease. Although the renin-angiotensin-aldosterone (RAA) system is enormously activated in this disease, there are few reports that attempt to characterize the effect of early use of RAA inhibitors (RASi) on the temporal course of kidney function.
Methods: This retrospective cohort study was conducted to clarify whether the early use of RASi during hospitalization offered more favorable benefits on short-term renal function and long-term renal outcomes in patients with hypertensive emergencies.