Publications by authors named "Takehiko Suzuki"
Article Synopsis
- Shiga toxin-producing E. coli (STEC) is a harmful pathogen linked to beef consumption, making its control in slaughterhouses vital to food safety.
- A study collected 524 samples from 12 Japanese slaughterhouses and tested for STEC presence, revealing small percentages of STEC O157:H7 and other stx-positive strains on beef carcasses.
- The research indicates a connection between higher levels of bacterial counts on carcasses and the likelihood of detecting STEC, emphasizing the need for improved hygiene practices in facilities with high contamination levels.
[Study of surgical procedures for retinal detachment with macular hole].
Nippon Ganka Gakkai Zasshi
May 2007
Purpose: To evaluate the surgical outcome of retinal reattachment, the reattachment rate according to the range of detachment, and postoperative visual acuity for macular hole retinal detachment (MHRD).
Subjects And Methods: Sixty-eight eyes of 67 patients with MHRD were analyzed. The mean follow-up period was 54 months.
For the multi-reservoir type microspheres composed of polylactide (PLA) and poly(dl-lactide-co-glycolide) (PLGA), the influence of inner drug-holding layer/outer layer ratio on drug release profiles was studied. The microspheres were prepared by the O/W type emulsion-solvent evaporation technique, and cisplatin was used as a model drug. The water-uptake and the erosion of each polymer were evaluated to clarify the mechanism of drug release for multi-reservoir type microspheres.
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- The study investigates how different layers in multi-reservoir microspheres made of PLGA and PLA affect drug release profiles using cisplatin as a model drug.
- The preparation method involved creating microspheres through a W/O emulsion-solvent evaporation technique, with varying drug distribution based on the blend ratio of PLA and PLGA.
- Key findings reveal that early drug release is influenced by its surface distribution, while steady-state release is primarily determined by the erosion of the drug-holding layer.
Purpose: To demonstrate the ability of a novel chromosomal marker to identify retinal pigment epithelium (RPE) after xenotransplantation, and determine the short-term correlation between pigment and this nuclear marker.
Methods: Primary pigmented RPE harvested from third trimester fetal pigs were transplanted as microaggregates into the subretinal space of 3 albino rabbits. We then used an in situ probe for a repetitive segment of the porcine chromosome to identify the transplanted RPE.
The aim of this study was to clarify the organ distribution of cisplatin (CDDP) after intraperitoneal (i.p.) administration of cisplatin-loaded microspheres (CDDP-MS).
View Article and Find Full Text PDFModification of the enzyme alginate lyase (AL) with poly(ethylene glycol) (PEG) was attempted for the degradation and removal of alginate biofilms in infectious diseases. The modification of AL with PEG was attempted with three kinds of N-succinimidyl succinate PEG (SS-PEG), which differed in molecular weight (i.e.
View Article and Find Full Text PDFThis study evaluates the anti-tumor effect of cisplatin-loaded microspheres (CDDP-MS) against peritoneal carcinomatosis using human tumor xenografts. The incorporated CDDP was released from CDDP-MS for 3 weeks in vivo as well as in vitro. CDDP-MS at a dose of 35 mg/kg (at maximal tolerable dose (MTD)) showed effective anti-tumor activity (tumor growth inhibition rate (IR)=70.
View Article and Find Full Text PDFThe aim of this study is to evaluate and compare the dissolution profiles of cisplatin-loaded microspheres (CDDP-MS) in vitro and in vivo, and to determine the relationship between the dissolution profiles in vitro and systemic toxicity. For this purpose, three types of CDDP-MS that release the CDDP for 1, 2 and 5 weeks without a large amount of initial release in phosphate buffered saline (pH 7.4) were prepared.
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