Publications by authors named "Takeharu Kato"

Article Synopsis
  • A 63-year-old man with relapsed acute myeloid leukemia underwent a third stem cell transplant and was given voriconazole to prevent fungal infections.
  • On day 42 post-transplant, he developed septic arthritis without the typical skin signs associated with fungal infections.
  • Despite surgery and treatment with liposomal amphotericin B, he died due to a resistant fungal infection, highlighting the need to consider azole-resistant infections as potential causes of septic arthritis in similar patients.
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  • * A retrospective analysis of 32 patients aged 70 and older showed that those treated with MOG-containing chemotherapy had a median survival time of 18.1 months and a 2-year overall survival rate of 45%, indicating improved outcomes compared to previous treatments.
  • * Adverse events from MOG treatment were similar to those seen in past studies, and while comorbidity impacted survival, the intensity of MOG treatment did not, suggesting a different action mechanism compared to
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  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can lead to long-lasting remission in adult T-cell leukemia/lymphoma (ATL) patients, but there's a lack of research on post-transplant outcomes for younger patients (≤49 years).
  • A study found that patients aged <40 years had a significantly better overall survival rate (61.8%) compared to those aged 40-49 years (43.1%), indicating younger patients fare better post-transplant.
  • Moreover, while there were no major differences in survival outcomes between different conditioning regimens, the reduced-intensity conditioning (RIC) regimen resulted in lower non-relapse mortality compared to the myeloablative conditioning (MAC) regimen
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Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive peripheral T-cell neoplasm with a poor prognosis. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) is an immune checkpoint receptor expressed on T and natural killer cells. Although increased TIGIT expression in the tumour microenvironment is associated with poor prognosis in various neoplasms, its relevance in ATLL remains unknown.

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Super-enhancers (SEs) play an important role in regulating tumor-specific gene expression. JQ1, a Bromodomain-containing protein 4 (BRD4) inhibitor, exerts antitumor effects by disrupting SE-mediated regulation of gene expression. We investigated the anti-adult T-cell leukemia/lymphoma (ATL) effects of JQ1.

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  • Iron-based 1111-type superconductors are known for their high critical temperatures and current densities, but traditional methods to increase current density (J) are limited.
  • Researchers improved J in SmFeAsOH films by increasing carrier density via high electron doping, which significantly reduced penetration depth and coherence length.
  • This innovative approach led to a remarkable increase in J to 415 MA/cm, comparable to cuprate superconductors, and demonstrated successful application across other iron-based superconductors as well.
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Extraterrestrial minerals on the surface of airless Solar System bodies undergo gradual alteration processes known as space weathering over long periods of time. The signatures of space weathering help us understand the phenomena occurring in the Solar System. However, meteorites rarely retain the signatures, making it impossible to study the space weathering processes precisely.

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γδ T cells and natural killer (NK) cells have attracted much attention as promising effector cell subsets for adoptive transfer for use in the treatment of malignant and infectious diseases, because they exhibit potent cytotoxic activity against a variety of malignant tumors, as well as virus-infected cells, in a major histocompatibility complex (MHC)-unrestricted manner. In addition, γδ T cells and NK cells express a high level of CD16, a receptor required for antibody-dependent cellular cytotoxicity. Adult T-cell leukemia-lymphoma (ATL) is caused by human T-lymphotropic virus type I (HTLV-1) and is characterized by the proliferation of malignant peripheral CD4 T cells.

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  • The study showcases a method for large-volume 3D reconstruction using plasma-focused ion beam-scanning electron microscopy (PFIB-SEM).
  • Researchers successfully created a 3D model of a Li-ion battery cathode measuring 750μm × 143μm × 310μm at a fine resolution of 200nm/pixel, using 1550 SEM images.
  • PFIB-SEM outperformed X-ray computed tomography in terms of both the volume of data that can be reconstructed and the quality of the resolution and contrast.
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Background: The impact of computed tomography (CT)-detected extramural venous invasion on the recurrence of colon cancer is not fully understood. The aim of this study was to investigate the clinical significance of extramural venous invasion diagnosed before surgery by contrast-enhanced CT colonography using three-dimensional multiplanar reconstruction images.

Methods: Patients with colon cancer staged greater than or equal to T2 and/or stage I-III who underwent contrast-enhanced CT colonography between 2013 and 2018 at the National Cancer Center Hospital in Japan were retrospectively investigated for CT-detected extramural venous invasion.

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  • Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) can be divided into two main subtypes: PTCL-TBX21 and PTCL-GATA3, each exhibiting different characteristics.
  • In a study involving 100 Japanese patients, PTCL-TBX21 showed better treatment response and lower CD4 positivity compared to PTCL-GATA3, which also had worse overall survival rates.
  • The findings suggest that classifying PTCL-NOS based on these subtypes can help predict patient outcomes and tailor immune therapy.
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  • * In a case involving a 78-year-old man, TBLC combined with endobronchial ultrasonography (EBUS) successfully diagnosed adult T-cell lymphoma (ATL), marking it as the first such diagnosis using this method.
  • * A review of literature found 19 total cases of pulmonary lymphomas diagnosed via TBLC, primarily B-cell lymphomas (84.2%), and highlighted the effectiveness and safety of this technique, suggesting more research is needed to refine diagnostic guidelines.
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In the samples collected from the asteroid Ryugu, magnetite displays natural remanent magnetization due to nebular magnetic field, whereas contemporaneously grown iron sulfide does not display stable remanent magnetization. To clarify this counterintuitive feature, we observed their nanoscale magnetic domain structures using electron holography and found that framboidal magnetites have an external magnetic field of 300 A m, similar to the bulk value, and its magnetic stability was enhanced by interactions with neighboring magnetites, permitting a disk magnetic field to be recorded. Micrometer-sized pyrrhotite showed a multidomain magnetic structure that was unable to retain natural remanent magnetization over a long time due to short relaxation time of magnetic-domain-wall movement, whereas submicron-sized sulfides formed a nonmagnetic phase.

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The prognosis of primary central nervous system lymphoma (PCNSL) in the elderly remains poor. We aimed to evaluate the outcome of rituximab, methotrexate, procarbazine, and vincristine (RMPV) chemotherapy in elderly patients with new-onset PCNSL. Twenty-eight patients aged ≥ 70 years treated for PCNSL between 2010 and 2020 were examined retrospectively.

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A 24-year-old man was admitted to our hospital because of severe heart failure. Although he was treated with diuretics and positive inotropic agents, his heart failure progressed. An endomyocardial biopsy revealed iron deposition in his myocytes.

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A 55-year old female patient was treated with methotrexate (MTX) and infliximab (IFX) for rheumatoid arthritis (RA). She experienced unknown fever, generalized lymphadenopathy, and liver tumors. Histological examination of the inguinal lymph node and a liver tumor resulted in the pathological diagnosis of classic Hodgkin lymphoma, with many Reed-Sternberg cells with the positivity of Epstein-Barr virus (EBV).

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An 86-year-old man presented with recurrence of hepatocellular carcinoma (HCC) after surgery. Atezolizumab plus bevacizumab was initiated. After the third course of atezolizumab plus bevacizumab therapy, petechial purpura appeared on the extremities and trunk.

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Introduction And Importance: Esophageal perforation due to stereotactic body radiotherapy (SBRT) is rare, and there is no consensus on the treatment strategy. Here, we report two cases of esophageal perforation caused by CyberKnife irradiation managed with distinct surgical approaches.

Case Presentation: Case 1 was a 54-year-old woman who was administered chemotherapy including bevacizumab and underwent CyberKnife SBRT for postoperative ovarian cancer (pStage IIIc) with metastasis in the eighth thoracic vertebra.

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A prolonged activated partial thromboplastin time (APTT) is observed in patients with severe fever with thrombocytopenia syndrome (SFTS) and is one of the risk factors for severe disease. The mechanism underlying a prolonged APTT is largely unknown. The presence of antiphospholipid (aPL) antibodies in various viral infections has been documented but never reported in a patient with SFTS.

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Donor lymphocyte infusion (DLI) is a therapeutic modality for relapsed hematological malignancies after allogeneic hematopoietic stem cell transplantation. We retrospectively analyzed non-infectious pulmonary complications (non-IPCs) following DLI therapy in 41 post-transplant patients with hematological malignancies, and found that 7 developed post-DLI non-IPCs. The 6-year cumulative incidence of non-IPCs was 18.

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Article Synopsis
  • Adult T-cell leukemia/lymphoma (ATL) has a very poor prognosis, and super-enhancers (SE) are potential targets for therapy as they influence tumor-specific gene expression.
  • The study found that alvocidib, a CDK9 inhibitor, effectively slowed down ATL cell growth by targeting the SEs that regulate the IRF4 gene, which is crucial for ATL cell proliferation.
  • Alvocidib showed promise in both cell lines and a mouse model, suggesting it could be a valuable treatment for ATL and potentially other cancers.
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