Publications by authors named "Takayuki Uemura"
Background: Obesity indices reflect not only fat mass but also muscle mass and nutritional status in older people. Therefore, they may not accurately reflect prognosis. This study aimed to investigate associations between a body shape index (ABSI), body mass index (BMI), and mortality in the general older population.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate the relationship between serum high-density lipoprotein cholesterol (HDL-C) levels and kidney outcomes in a large sample of the general Japanese population.
- Using data from the Japan Specific Health Checkups Study, researchers analyzed the risk of a 40% decline in estimated glomerular filtration rate (eGFR) in relation to different HDL-C levels.
- Findings indicated that low HDL-C levels (under 60 mg/dL) were linked to an increased risk of kidney function decline, while high HDL-C levels did not show adverse effects on kidney outcomes.
Article Synopsis
- Diabetic patients and the elderly often experience high pulse pressure (PP), but research on how it relates to kidney damage (microangiopathy and macroangiopathy) is limited.
- A study with 408 diabetic nephropathy patients evaluated the link between PP at kidney biopsy and kidney failure requiring replacement therapy (KFRT) over a median follow-up of 6.7 years.
- Results indicated that higher PP correlates with increased KFRT risk and is significantly associated with specific kidney lesions, although not with certain types of thickening in blood vessels.
Background: Unlike systolic blood pressure (SBP), the prognostic value of diastolic blood pressure (DBP) in kidney function has not been established. We hypothesized that pulse pressure (PP), which is associated with arteriosclerosis, would affect the prognostic value of DBP.
Methods: This longitudinal study used data from the Japan Specific Health Checkups Study was conducted between 2008 and 2014.
Background: Studies on kidney function and histological findings in diabetic nephropathy (DN) with low urinary protein (UP) are few. We examined the differential impact of histological changes on kidney outcomes between non-proteinuric and proteinuric DN.
Methods: Patients diagnosed with DN by renal biopsy during 1981-2014 were divided into non-proteinuric (UP ≤ 0.
Aim: To examine whether serum β2-microglobulin (β2-MG) could improve the prediction performance for kidney failure with replacement therapy (KFRT) among patients with diabetic nephropathy (DN).
Methods: Patients with biopsy-proven DN at Nara Medical University Hospital were included. The exposure of interest was log-transformed serum β2-MG levels measured at kidney biopsy.
Article Synopsis
- - The study aimed to explore how isolated hematuria (blood in urine) affects kidney function decline, particularly looking at how proteinuria (excess protein in urine) might influence this relationship.
- - An analysis of over 552,000 participants revealed that those with hematuria experienced a faster decline in kidney function compared to those without, particularly when proteinuria was present.
- - The findings indicate that while hematuria alone can lead to a slight decline in kidney function, the presence of proteinuria intensifies this decline, suggesting a compounded effect on kidney health.
Article Synopsis
- Microalbuminuria is linked to serious health issues like kidney disease and cardiovascular problems, but the impact of trace proteinuria (found in dipstick tests) on kidney health is less clear.* -
- A study involving over 306,000 participants showed that those with trace proteinuria had a significantly higher risk of developing worsened kidney function and overt proteinuria over an average follow-up of 36 months.* -
- The findings suggest that even minor traces of protein in urine can indicate an increased likelihood of kidney decline, highlighting the importance of monitoring kidney health in the general population.*
Article Synopsis
- The study examines the link between height loss and kidney function in older adults, as height loss can indicate issues like osteoporosis and sarcopenia and may correlate with negative health outcomes.
- It utilized data from the Japan Specific Health Checkups Study (2008-2014), tracking height changes and kidney outcomes over multiple visits using statistical models.
- Results showed that participants with the greatest height loss experienced a significant increase in serum creatinine levels and faster decline in kidney function compared to those with minimal height loss.
Increased triglycerides (TG) and decreased high-density lipoprotein cholesterol (HDL-C) are dyslipidemias characteristic of diabetes. Here, we aimed to examine associations of TG/HDL-C ratio with cardiovascular disease (CVD) and kidney dysfunction among patients with diabetic nephropathy. This retrospective observational study consists of patients with biopsy-proven diabetic nephropathy at Nara Medical University Hospital.
View Article and Find Full Text PDFBackground: Immunoglobulin A nephropathy (IgAN) is the most common type of primary glomerulonephritis. Since most patients have a relatively benign renal prognosis, long-term follow-up is required. During such a long course of disease, relapse of IgAN is occasionally observed after upper respiratory tract infection or without any trigger.
View Article and Find Full Text PDFTAFRO syndrome is a rare systemic inflammatory disorder that is characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly. Progressive renal involvement is frequently observed in patients with TAFRO syndrome, and the renal histological findings remain limited. A 52-year-old man with thymoma that was detected by chest computed tomography was admitted to our hospital because of dyspnea and abdominal distension.
View Article and Find Full Text PDFPeritonitis is a critical complication of peritoneal dialysis (PD). Investigators have reported the risk of peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD) versus automated peritoneal dialysis (APD), but the available evidence is predominantly based on observational studies which failed to report on the connection type. Our understanding of the relationship between peritonitis risk and PD modality thus remained insufficient.
View Article and Find Full Text PDFAn increasing number of invasive infections due to Streptococcus agalactiae in non-pregnant adults have been reported. We report a case of infective endocarditis complicated by intraventricular abscesses, pericarditis, and mycotic aneurysm due to S. agalactiae belonging to ST681 with a capsular serotype VI in a woman with diabetes.
View Article and Find Full Text PDF