Publications by authors named "Takayuki Shimoshikiryo"
Article Synopsis
- Inflammation reduces the activity of cytochrome P450 3A (CYP3A), and the NLRP3 gene is linked to regulating inflammation, especially in diseases like asthma.
- A study examined 10 specific NLRP3 genetic variations (SNPs) in 152 asthma patients to see how these affect plasma levels of 4β-hydroxycholesterol (4βOHC), a marker for CYP3A activity.
- Results indicated that certain SNPs were associated with lower 4βOHC levels and higher interleukin-6 (IL-6) concentrations, suggesting that NLRP3 polymorphisms could serve as potential indicators of CYP3A activity in asthma patients.
Background: It remains unclear how to characterize different subtypes of asthma and chronic obstructive pulmonary disease (COPD). We previously described serum periostin and chitinase-3-like protein 1 (YKL-40) as useful markers for asthma-COPD overlap (ACO). MicroRNAs (miRNAs) are now recognized as markers for identifying the pathophysiological features in several diseases.
View Article and Find Full Text PDFBackground: Augmented renal clearance (ARC) has frequently been observed in critically ill patients. The risk factors for ARC in patients, including those in the general ward, and their influences on vancomycin (VCM) treatment remain unclear. The aims of this study were to investigate the risk factors for ARC and to evaluate the influence of ARC on the pharmacokinetic parameters of VCM.
View Article and Find Full Text PDFPurpose: The long-term efficacy of tolvaptan, a vasopressin V2 receptor antagonist, has been reported. However, the safety of long-term treatment remains to be fully elucidated. We assessed the safety profile of tolvaptan with respect to hypernatremia.
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