Publications by authors named "Takayuki Mizorogi"

Article Synopsis
  • Aging domestic cats show notable increases in body weight and body condition score (BCS), with various metabolic changes in their serum as they age.
  • The study involved 70 cats categorized into six age groups, where levels of glucose, triglycerides, and other markers related to energy metabolism were measured.
  • Findings reveal that older cats typically have higher serum glucose and triglycerides, alongside increased inflammatory markers, while certain indicators like albumin levels decrease and metabolic ratios shift negatively compared to younger cats.
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Background: Obesity has become a serious public health problem all over the world, and prevalence of obesity has increased in cats. Obesity is characterized by continuous low-grade inflammation based on oxidative stress by excessively produced reactive oxygen species (ROS). Supplementation with anti-oxidant and anti-inflammatory compounds is very effective to relieve the obesity condition.

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Accumulated visceral and subcutaneous fat masses were measured with computed tomography (CT) in cats with various body condition scores (BCS) from 5/9 to 9/9. BCS does not always reflect visceral fat accumulation which induces pro-inflammatory reactions. Obese cats with accumulated visceral fat showed low plasma adiponectin and high serum amyloid A (SAA) concentrations, an inflammatory marker.

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The aim of this study is to discuss the effect of anti-oxidant supplement (Rv-PEM01-99, Kibun Foods, Inc., Tokyo, Japan) on changes in energy metabolism in obese dogs. 200 mg/kg/day of Rv-PEM01-99 (equivalent to 5 mg kg/day of quercetin derivative) were applied for 6 weeks to the Beagle dogs fed high fat diet (HFD) or control diet (CD).

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