Publications by authors named "Takayuki Mihara"
We conducted a systematic review and meta-analysis to examine the efficacy profiles of metronidazole (MNZ) and vancomycin (VCM) in pediatric and adolescent patients with Clostridioides difficile infection (CDI). A systematic review and meta-analysis was conducted using four electronic databases (PubMed, Cochrane Library, Web of Science, and Clinicaltrials.gov) through July 6, 2022.
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- A combination of chlorhexidine gluconate and alcohol (CHG-alcohol) is recommended for surgical skin prep to reduce the risk of surgical site infections (SSI), but there's no clear agreement on the ideal concentration of CHG.
- A systematic review and meta-analysis compared SSI rates between CHG-alcohol and povidone-iodine across different CHG concentrations, specifically 0.5%, 2.0%, 2.5%, and 4.0%.
- The findings indicated that 0.5% and 2.0% CHG-alcohol significantly reduced SSI rates compared to povidone-iodine, while higher concentrations did not show a notable difference, affirming the effectiveness of lower
Background: Fidaxomicin (FDX) has received considerable attention as a novel therapeutic alternative agent to vancomycin (VCM) for Clostridioides difficile infection (CDI). However, the superiority and efficacy profile of FDX are not sufficiently determined by high-quality evidence. This study aimed to clarify the superiority of FDX for CDI treatment through a systematic review and meta-analysis.
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