Publications by authors named "Takayuki Matsumae"
Background: Intraductal papillary mucinous neoplasia (IPMN) is a risk factor for pancreatic cancer (PC). PC concomitant with IPMN shows rapid progression similar to de novo PC, therefore, the appropriate observation interval (OI) is not yet clear.
Patients And Method: This was a multicenter retrospective observational study, and patients with PC concomitant with IPMN were analyzed.
Background: Pancreatitis is known to be an important risk factor for pancreatic ductal adenocarcinoma (PDAC). However, the exact molecular mechanisms of how inflammation promotes PDAC are still not fully understood. Regnase-1, an endoribonuclease, regulates immune responses by degrading mRNAs of inflammation-related genes.
View Article and Find Full Text PDFWe evaluated the value of secreted glycoprotein thrombospondin-2 (TSP-2) to predict hepatocellular carcinoma (HCC) occurrence in chronic hepatitis C (CHC) patients after Hepatitis C virus (HCV) elimination by direct-acting antiviral agents (DAAs). A total of 786 CHC patients without an HCC history who achieved a sustained virological response (SVR) with DAAs were randomly assigned 2:1, with 524 patients as the derivation cohort and 262 patients as the validation cohort. Serum TSP-2 levels at the end of treatment were measured by enzyme-linked immunosorbent assay (ELISA).
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- Combination immunotherapy using anti-PD-L1 and anti-VEGF antibodies is the standard treatment for patients with unresectable HCC, but it doesn’t benefit all patients equally.
- A study involving 85 HCC patients showed that high levels of cell-free DNA (cfDNA) in the blood correlate with poorer treatment responses and shorter survival outcomes.
- Specific mutations in ctDNA, particularly in the TERT gene, can indicate worse prognosis and may help doctors assess treatment effectiveness for patients receiving this therapy.
Article Synopsis
- * Researchers looked at blood biomarkers to see if they could predict which patients would be nonresponders, finding that high levels of IL-6 and interferon alpha (IFNα) were significant predictors.
- * Patients with high IL-6 levels had worse outcomes, such as shorter progression-free survival and overall survival, making IL-6 a potential new prognostic biomarker for those receiving this therapy.
Rectal neuroendocrine tumors grade 1 (NET G1; carcinoid) ≤ 10 mm in diameter often extend into the submucosa, making their complete histological resection difficult using endoscopic techniques. Endoscopic submucosal resection with a ligation device (ESMR-L) and endoscopic submucosal dissection (ESD) are commonly used to overcome these difficulties. We also previously reported that underwater endoscopic mucosal resection (UEMR) could facilitate resection of rectal NET G1.
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