Distribution of FIB-4 index in the general population: analysis of 75,666 residents who underwent health checkups.

Background: Fatty liver is frequently found in a general population, and it is critical to detect advanced fibrosis. FIB-4 index is considered a useful marker for evaluating liver fibrosis but the distribution of FIB-4 index in the general population remains unknown.

Methods: This cross-sectional study included residents who underwent ultrasonography at health checkups in Hiroshima or Iwate prefectures.

Relationship between drinking frequency and fatty liver prevalence or incidence in Japanese undergoing health checkup in 2008-2019.

Background & Aims: The relationship between the frequency of drinking and fatty liver in the general population is still poorly understood. This study analysed data from a large cohort who underwent health checkups in Japan between 2008 and 2019 to investigate the prevalence and incidence of fatty liver by alcohol consumption and risk factors for fatty liver.

Methods: The prevalence of fatty liver diagnosed with ultrasonography was calculated in 75,670 residents.

Very low prevalence of anti-HAV in Japan: high potential for future outbreak.

Since the early 21 century, almost all developed countries have had a very low hepatitis A virus antibody (anti-HAV) sero-prevalence profile, as sanitation conditions and health care facilities have been optimized to a universal standard. There has not been a report on anti-HAV prevalence among a large scale population in Japan since 2003. Therefore, this study aimed to investigate the current HAV status among the general population in Hiroshima.

Incidence and risk factors of colorectal cancer based on 56 324 health checkups: A 7-year retrospective cohort study.

Background And Aim: Although mortality rates of colorectal cancer (CRC) have been increasing in Japan, its screening rates remain stagnant at 19.2% among Japanese population aged > 40 years in 2014. To evaluate the importance of CRC screening by fecal occult blood test (FOBT), this study estimated the incidence of FOBT-positivity and CRC by sex-age stratification and clarified the risk factors for CRC.