Publications by authors named "Takayuki Goto"
Purpose: Circulating tumor DNA (ctDNA) analysis is an alternative to tissue biopsy for genotyping in various cancers. We aimed to establish a plasma ctDNA sequencing assay, then evaluate its clinical utility in advanced urothelial cancer (UC).
Materials And Methods: This study included 82 patients with muscle-invasive or metastatic UC.
We retrospectively analyzed the regions and perioperative outcomes associated with lymph node dissection in patients with prostate cancer. Of 543 patients who underwent robot-assisted radical prostatectomy for prostate cancer with or without lymph node dissection according to the modified D'Amico criteria, 333 (61.3%), 128 (23.
View Article and Find Full Text PDFPurpose: To evaluate functional and oncological outcomes in patients who underwent unilateral or bilateral nerve-sparing (NS) robot-assisted radical prostatectomy (RARP) for high-risk prostate cancer.
Methods: The cohort comprised 2683 patients with clinical stage T1-4, N0M0 high-risk prostate cancer who underwent RARP in Japanese tertiary care centers from August 2011 to April 2023. High risk was defined using the European Association of Urology risk stratification criteria.
Plasmablastic lymphoma (PBL) is a malignant lymphoma with poor prognosis that occurs in immunocompromised and elderly patients. We describe the case of a 75-year-old woman with PBL as a methotrexate-associated lymphoproliferative disorder (MTX-LPD). She presented with multiple oral ulcers and mass-like shadows in the lung fields.
View Article and Find Full Text PDFBackground: In Japan, since 2014, new treatments such as androgen receptor signaling inhibitors and cabazitaxel have become applicable for metastatic castration-resistant prostate cancer (mCRPC), leading to dramatic changes in treatment options.
Objective: This study aims to evaluate the impact of recent advancements in treatment options on the overall survival (OS) of patients diagnosed with de novo metastatic castration-sensitive prostate cancer (mCSPC) in Japan.
Methods: A retrospective analysis was conducted on 2450 Japanese men diagnosed with de novo mCSPC between 2008 and 2018.
Background: Visualizing the specific regions where atrial fibrillation (AF) is maintained is crucial for effective treatment, but it remains challenging in clinical practice. We aimed to address this challenge by developing a mapping approach focused on the cycle length (CL) and its gradient (CL-gradient).
Methods: In 105 patients undergoing initial ablation for persistent AF, pre-ablation CARTOFINDER data were utilized to create maps based on three indicators: (1) CL, the atrial frequency during AF calculated using CARTOFINDER; (2) Short CL, encompassing CLs within 5 ms of the minimum CL; and (3) CL-gradient, the CL range within a 6 mm radius.
A 68-year-old male was referred to our hospital because plain computed tomography (CT) showed right hydronephrosis. Contrast-enhanced CT revealed a mass with an irregular margin and poor contrast effect in the lower pole of the right kidney, which invaded the perirenal fat tissues and the area around the inferior vena cava (IVC). Moreover, a thrombus extending from the right renal vein to the IVC was detected, some of which was suggestive of tumor components on contrast-enhanced magnetic resonance imaging (MRI).
View Article and Find Full Text PDFArticle Synopsis
- The study examined postoperative complication rates in elderly prostate cancer patients undergoing robot-assisted radical prostatectomy (RARP) across various age groups.
- A total of 8,055 patients were analyzed, revealing similar complication rates for those under 70 and those aged 75 or older.
- The conclusion indicated that age alone does not significantly increase the risk of complications after RARP in well-selected elderly patients, suggesting that surgery can be safely performed on older populations.
Objective: To evaluate comorbidities in Japanese testicular cancer (TC) survivors in a multi-institutional, cross-sectional study.
Methods: This study enrolled TC survivors who visited any of the eight high-volume institutions in Japan from 2018 to 2019. After obtaining informed consent, participants answered questionnaires about their comorbidities.
Article Synopsis
- Cytokine release syndrome (CRS) is a common side effect of CAR-T cell therapy, which can sometimes manifest as localized CRS (L-CRS) affecting specific areas like the larynx.
- A 67-year-old woman with transformed follicular lymphoma experienced laryngeal edema after CAR-T treatment, requiring tracheal intubation due to inadequate response to standard treatments (tocilizumab and dexamethasone).
- Key takeaways include recognizing that CAR-T therapy can lead to serious L-CRS like laryngeal edema, that TCZ alone may not be effective for cervical L-CRS, and the importance of prompt management to prevent airway complications.
Background: The fibrosis-5 (FIB-5) index is a noninvasive marker for assessing the progression of liver fibrosis and predictor in patients with heart failure (HF). This study investigated the association between the FIB-5 index and response to cardiac resynchronization therapy (CRT) and evaluated its predictive value for prognosis.
Methods: In total, 203 patients who underwent CRT/CRT-defibrillator (CRT-D) implantation were retrospectively included.
Background: Active surveillance for prostate cancer was initiated in the early 2000s. We assessed the long-term outcomes of active surveillance in Japan.
Methods: This multicenter prospective observational cohort study enrolled men aged 50-80 years with stage cT1cN0M0 prostate cancer in 2002 and 2003.
Article Synopsis
- - A new prognostic model was developed to predict cancer-specific survival (CSS) for patients with de novo metastatic hormone-sensitive prostate cancer (mHSPC) using data from 1,092 Japanese patients treated between 2014 and 2020.
- - Key factors for predicting CSS included disease severity, liver metastasis, certain lab results, and primary tumor characteristics, leading to significant differences in 5-year CSS rates among low-risk (86%) and high-risk (22%) groups.
- - This model displayed high accuracy and reproducibility, and it may help tailor treatment approaches for patients with mHSPC, especially in determining the intensity of therapies needed.
Objective: To report the outcomes of repeat biopsies, metastasis and survival in the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study, a prospective observational study for Japanese patients, initiated in 2010.
Patients And Methods: At the beginning, inclusion criteria were initially low-risk patients, prostate-specific antigen (PSA) density (PSAD) <0.2, and ≤2 positive biopsy cores.
Article Synopsis
- The study examines the effectiveness of salvage radiotherapy in patients with biochemical recurrence after prostatectomy, focusing on factors that influence patient outcomes.
- It evaluated 67 patients from 2005 to 2019, finding a 5-year biochemical recurrence-free survival (bRFS) rate of 47.1%, with key factors like PSA doubling time and surgical margins impacting survival rates.
- The research concludes that a PSA doubling time of less than 6 months and positive surgical margins predict worse outcomes for salvage radiotherapy, while no serious side effects were reported.
The fan cooling vest is coming into very common use by Japanese outdoor manual workers. We examined that to what extent using this vest reduces thermal strain and perception during outdoor exercise in the heat on a sunny summer day. Ten male baseball players in high school conducted two baseball training sessions for 2-h with (VEST) or without (CON) a commercially available fan cooling vest on a baseball uniform.
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- The study aimed to examine the spatial relationship between primary and recurrent prostate tumors after patients underwent external-beam radiation therapy using PSMA-targeted PET/CT scans.
- Researchers analyzed data from a previous trial focusing on recurrent prostate cancer detected through PET/CT and divided the prostate into 14 sections to assess overlap between tumors.
- Results showed that 25% of recurrent tumors were found at the same site as the primary tumor, while 41.7% had partial overlap, suggesting that recurrent tumors often arise near the original tumor location.
Article Synopsis
- Liquid biopsy is a minimally invasive method for detecting cancer-related abnormalities, showing promise especially in prostate cancer and the development of new therapies.
- There are ongoing challenges in effectively screening, risk stratification, and treatment decisions for advanced prostate cancer that necessitate better biomarkers.
- The review highlights both the progress and the obstacles in integrating liquid biopsies into clinical practice, focusing on improvements needed in sample handling, data interpretation, and overall implementation for personalized treatment.
Importance: Although the cognitive components of behavioral therapy for overactive bladder (OAB) are widely recognized, there is a lack of studies evaluating the effectiveness of multicomponent interventions that include cognitive components as a treatment for OAB.
Objective: To examine the efficacy of a multicomponent intervention in improving health-related quality of life (HRQOL) for women with moderate to severe OAB.
Design, Setting, And Participants: This multicenter, open-label, randomized clinical trial was conducted in Japan among women aged 20 to 80 years who had moderate to severe OAB.
This study aimed to assess the effects of thienopyridine-class antiplatelet agents (including ticlopidine, clopidogrel, and prasugrel) on bleeding complications in patients who underwent robot-assisted radical prostatectomy. This cohort study used a database for robot-assisted radical prostatectomy at 23 tertiary centers nationwide between 2011 and 2022. Patients who received thienopyridines (thienopyridine group) were compared with those who received aspirin monotherapy (aspirin group).
View Article and Find Full Text PDFKey Clinical Message: Maintaining a disease-free status for a long time in cases of renal cell carcinoma with multiple bone metastases and repeated recurrences is challenging. What matters most in the multidisciplinary approach is the treatment strategy. Although this is a case where multidisciplinary treatment resulted in long-term CR during the TKI era, the treatment strategy is still relevant now that treatment options have increased.
View Article and Find Full Text PDFIntroduction: Intrinsic antitachycardia pacing (iATP) is a novel automated antitachycardia pacing (ATP) that provides individual treatment to terminate ventricular tachycardia (VT). However, the clinical efficacy of iATP in comparison with conventional ATP is unknown. We aim to compare the termination rate of VT between iATP and conventional ATP in patients with implantable cardioverter-defibrillators using a unique setting of different sequential orders of both ATP algorisms.
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- The study investigates the long-term effects of prostate position-based image-guided radiotherapy (P-IGRT) on patients with localized prostate cancer compared to traditional intensity-modulated radiation therapy (IMRT) without P-IGRT.
- A total of 222 patients were analyzed, and the results showed that the P-IGRT group had a higher biochemical failure-free rate (94.9% vs 82.7%) and lower rates of rectal bleeding requiring intervention.
- The findings suggest that using P-IGRT with higher doses and smaller margins may lead to better disease control and fewer side effects, highlighting its potential benefits in treating intermediate-risk prostate cancer.