Publications by authors named "Takayoshi Nishimoto"
Article Synopsis
- Small bowel adenocarcinoma (SBA) is uncommon, and this study investigates its molecular features and clinicopathologic characteristics through analysis of 68 patient samples.* -
- Researchers conducted immunohistochemical analyses on various markers and classified tumor mucin phenotypes while performing genomic profiling on 30 cases to understand correlations with tumor location, histology, and prognosis.* -
- The study finds significant associations between immunophenotypes and clinicopathologic features, suggesting that gastric-type SBA and intestinal-type SBA have different molecular pathways involved in their carcinogenesis.*
Background: Comprehensive genomic analysis has shown that small bowel adenocarcinoma (SBA) has different genomic profiles from gastric and colorectal cancers. Hence, it is essential to establish chemotherapeutic regimens based on SBA characteristics. The expression of programmed cell death-ligand 1 (PD-L1) and programmed cell death-ligand 2 (PD-L2) in SBA is not fully understood.
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- Linked color imaging (LCI) enhances the detection of colorectal polyps during colonoscopy, particularly for polyps less than 10 mm in size that may need treatment.* -
- A randomized trial involving 594 patients found that detection rates for adenoma polyps ≥5 mm were significantly higher with LCI compared to white light imaging (WLI), especially for those between 5-9 mm.* -
- The results suggest that LCI offers a clear advantage in visualizing polyps that are clinically important for endoscopic resection, making it an effective tool for colon cancer prevention.*
The frequency of primary small intestinal adenocarcinoma is increasing but is still low. Its frequency is approximately 3% of that of colorectal adenocarcinoma. Considering that the small intestine occupies 90% of the surface area of the gastrointestinal tract, small intestinal adenocarcinoma is very rare.
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- This study analyzed genomic alterations in small bowel adenocarcinomas (SBAs) from 22 Japanese patients using targeted next-generation sequencing (NGS) to enhance understanding of this rare cancer in an Asian population.
- The most frequent mutations found were in the TP53, KRAS, and APC genes, with specific tumor characteristics like mucin type and mismatch repair (MMR) status affecting mutation profiles.
- No single gene mutation was associated with overall survival, but patients with KRAS mutations had significantly worse outcomes if they also had proficient MMR tumors.
Background And Aim: Helicobacter pylori infection is a primary cause of gastroduodenal ulcers. To investigate whether there is an association between H. pylori infection and small intestinal mucosal injury.
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