Publications by authors named "Takayama M"
Background: Alcohol septal ablation (ASA) is used to treat drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). Intraprocedural echocardiography is essential for identifying the septal area perfused by each septal branch; however, its role in determining the procedural endpoint of ASA remains unclear. This retrospective study aimed to evaluate the impact of intraprocedural echocardiographic findings on clinical outcomes and left ventricular pressure gradient (LVPG) after ASA.
View Article and Find Full Text PDF() is known to cause intra-abdominal and anaerobic bloodstream infections. However, clinical insights and information on antimicrobial susceptibility in infections are limited. This study aimed to elucidate the clinical characteristics and antimicrobial susceptibility of infections.
View Article and Find Full Text PDFBackground: The delayed-window indocyanine green (DWICG) technique is useful for the removal of brain and spinal tumors.
Case Description: A 41-year-old female presented with lower left back and radicular pain. An magnetic resonance imaging (MRI) revealed an extramedullary L3 lesion located ventrally in the spinal canal that appeared to be a schwannoma.
The McLafferty rearrangement (McLR) of the methyl valerate molecular ion has been comprehensively studied from the standpoints of the timescale for the keto-enol transformation and the change of the configuration of intermediates and transition state (TS), using mass spectrometry with electron ionization, strong-field tunnel ionization and collision-induced dissociation methods, and the global reaction route mapping (GRRM) program with quantum chemical calculations (QCCs). The timescales estimated from mass spectrometric results suggested that the McLR starts at 100 fs after ionization and is completed at least within 100 ns in the ion source. Whereas the timescales are consistent with a stepwise mechanism of fast (100 fs) and slow (10 ps) steps presented by Stamm , the QCCs put forth the possibility that an unanticipated, rapid, concerted process may be involved in completing the McLR reaction.
View Article and Find Full Text PDFThe SARS-CoV-2 pandemic alerted the potential for significant harm due to future cross-species transmission of various animal coronaviruses to human. There is a significant need of antibody-based drugs to treat patients infected with previously unseen coronaviruses. In this study, we generated CV804, an antibody that binds to the S2 domain of SARS-CoV-2 spike protein, which is highly conserved across the coronavirus family and less susceptible to mutations.
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- * This study outlines a repair method using the Gore Preclude MVP Dura Substitute, a three-layer artificial material that effectively closes the dural opening.
- * The procedure involved placing a larger piece of MVP in the durotomy area, securing it with nylon yarn, which successfully prevented any leaks and resulted in no complications during the process.
Article Synopsis
- Diabetes is a significant risk factor for cardiovascular diseases but exhibits a "diabetes paradox" in Takotsubo syndrome, where it may not negatively affect outcomes, although this remains debated.
- In a study analyzing 1,226 Takotsubo syndrome patients, the prevalence of diabetes was found to be similar to that of the general population (17.0% vs. 15.8%).
- The study concluded that diabetes does not have a protective effect in Takotsubo syndrome and may even be linked to higher in-hospital mortality rates, challenging the belief that diabetes could be beneficial in this context.
Hypertrophic cardiomyopathy is characterized by significant left ventricular wall thickening, often leading to obstructive symptoms. Alcohol septal ablation (ASA) has emerged as an effective treatment for patients with hypertrophic obstructive cardiomyopathy (HOCM) who remain symptomatic despite maximal medical therapy. However, the detailed long-term effects of ASA in Japanese patients with HOCM remain unclear.
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- Contrast-enhanced intraoperative ultrasonography (CE-IOUS) is important for identifying colorectal liver metastases (CLM) during surgeries, but using artificial intelligence in this field has been limited.
- The study created an automatic tumor detection model using a Mask region-based convolutional neural network (Mask R-CNN), utilizing CE-IOUS images from 121 patients, resulting in two initial models (BRM and SM) and a combined model (CM).
- The combined model (CM) showed the best performance with a 96.5% accuracy and an AUC of 0.99, indicating that the integration of image- and algorithm-based methods significantly improves CLM detection.
Background: Filum terminale lipomas (FTLs) are congenital lumbosacral anomalies that can cause tethered cord syndrome (TCS). Most patients with TCS caused by FTL are children, and these are only rarely present in adults.
Case Description: A 64-year-old male presented with long-standing bilateral lower-limb weakness and bladder dysfunction.
Meigs syndrome after treatment for catamenial pneumothorax.
Gen Thorac Cardiovasc Surg Cases
November 2023
Article Synopsis
- Catamenial pneumothorax (CP) is a rare condition affecting women, characterized by a collapsed lung associated with menstrual cycles, while Meigs syndrome (MS) involves benign ovarian tumors causing pleural effusion and ascites, and its exact causes are not well understood.
- A 40-year-old Japanese woman was diagnosed with CP after experiencing dyspnea and undergoing surgery that revealed diaphragmatic foramens.
- Ten years later, the same patient presented with chest pain and imaging showed signs of MS, leading to surgery that resolved her symptoms, highlighting the rare occurrence of both conditions in one patient and suggesting links between them.
Article Synopsis
- Mavacamten, a cardiac myosin inhibitor, showed significant improvements in symptoms and heart function in Japanese patients with obstructive hypertrophic cardiomyopathy (HCM) during the HORIZON-HCM study.
- In a trial involving 38 patients, 36 completed the 30-week treatment, which resulted in a notable reduction in postexercise left ventricular outflow tract (LVOT) gradient and improvements in cardiac biomarkers and quality of life metrics.
- The treatment was well tolerated, with adverse events reported but none leading to discontinuation, and no deaths occurred throughout the study.
The molecular ion M was observed when the liquid sample of butyrophenone was supplied using atmospheric pressure corona discharge (APCD). In contrast, the vapor supply resulted in the formation of the protonated molecule [M+H]. The mass spectrum obtained with the liquid supply showed two distinctive fragment ions at 105 and 120, resulting from α-cleavage and McLafferty rearrangement (McLR), respectively.
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- A history of hospitalization for heart failure (HHF) before transcatheter aortic valve implantation (TAVI) is linked to poorer clinical outcomes in patients with severe aortic stenosis (AS).
- In a study of 2,752 patients, those with prior HHF had significantly higher 30-day mortality and overall risk of negative outcomes compared to those without such a history.
- The findings highlight that prior HHF affects patients regardless of their heart function, emphasizing the need for careful evaluation and management in these cases post-TAVI.
Article Synopsis
- Researchers analyzed the characteristics and outcomes of 22,236 patients with myocardial infarction, focusing on the 286 diagnosed with non-obstructive coronary arteries (MINOCA) from the Japan Acute Myocardial Infarction Registry.
- MINOCA patients were generally younger and had fewer risk factors compared to those with obstructive coronary artery disease (MI-CAD), but in-hospital mortality rates were similar between the two groups.
- The study found higher non-cardiac mortality in MINOCA patients, especially among the elderly, indicating a need for better overall management and care for younger patients to improve their health outcomes.
AHCC inhibited hepatic stellate cells activation by regulation of cytoglobin induction via TLR2-SAPK/JNK pathway and collagen production via TLR4-NF-κβ pathway.
Am J Physiol Gastrointest Liver Physiol
December 2024
Cirrhosis, which represents the end stage of liver fibrosis, remains a life-threatening condition without effective treatment. Therefore, prevention of the progression of liver fibrosis through lifestyle habits such as diet and exercise is crucial. The functional food AHCC, a standardized extract of cultured Lentinula edodes mycelia produced by Amino Up Co.
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- Both imagery and acupuncture are ancient medical practices, and a new treatment called video-guided acupuncture imagery treatment (VGAIT) combines both.
- A study with 12 participants examined how VGAIT affects pain threshold and brain wave activity, comparing it to a placebo acupuncture and a control group.
- Results showed that VGAIT significantly increased pain thresholds and specific brain wave activity, suggesting its potential as a remote treatment for pain.
Article Synopsis
- * Recent advancements in ocular genetics include identifying specific mutations, such as those in the EYS gene, which is often responsible for retinitis pigmentosa (RP), and exploring complex gene structures associated with other eye conditions.
- * Effective genome medicine relies on accurate patient diagnosis, understanding genetic patterns, and providing thorough genetic counseling, emphasizing the importance of clear communication between healthcare providers and patients regarding genetic diseases.
Article Synopsis
- The study examined the effects of the vasopressin V receptor antagonist tolvaptan on mortality in congestive heart failure (CHF) patients with hypoperfusion.
- Data from 5511 CHF patients showed that those with the wet-cold pattern (hypoperfusion) had significantly higher in-hospital mortality compared to those without.
- Tolvaptan was linked to reduced in-hospital mortality specifically in the CHF patients with hypoperfusion, suggesting potential tailored treatments for different CHF patient profiles.
Background: Intradiscal gas is frequently observed in older patients with disc degeneration and can occasionally result in nerve root compression.
Case Description: A 79-year-old male patient presented with increasing left lower extremity sciatica. Lumbar computed tomography (CT) and magnetic resonance (MR) images revealed a left paramedian L5-S1 gas-containing disc herniation.
Article Synopsis
- A study examined the link between malnutrition and oral health in older adults (aged 85+) using the GLIM criteria for diagnosing malnutrition, involving 519 participants from Tokyo.
- Findings revealed that 17.1% of participants were malnourished and had significant issues in oral health such as decreased maximum occlusal force, meal enjoyment, and various specific oral health problems.
- Cox regression analysis indicated specific oral health declines and problems (like difficulty in eating and maintaining teeth) were strongly associated with increased malnutrition risk among the elderly.
Article Synopsis
- * Recent findings emphasize that the mitral valve, papillary muscle issues, and an apical-basal muscle bundle also contribute significantly to this obstruction, not just the typical septal hypertrophy.
- * Four-dimensional computed tomography is recommended for detailed assessment and planning of surgical intervention in HCM, offering better imaging capabilities than traditional methods like echocardiography or cardiac MRI.